Population connectivity patterns of genetic diversity, immune responses and exposure to infectious pneumonia in a metapopulation of desert bighorn sheep.

التفاصيل البيبلوغرافية
العنوان:	Population connectivity patterns of genetic diversity, immune responses and exposure to infectious pneumonia in a metapopulation of desert bighorn sheep.
المؤلفون:	Dugovich BS; Department of Integrative Biology, Oregon State University, Corvallis, Oregon, USA., Beechler BR; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA., Dolan BP; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA., Crowhurst RS; Department of Fisheries, Wildlife, and Conservation Sciences, Oregon State University, Corvallis, Oregon, USA., Gonzales BJ; California Department of Fish and Wildlife, Rancho Cordova, California, USA., Powers JG; National Park Service, Biological Resources Division, Fort Collins, Colorado, USA., Hughson DL; National Park Service, Mojave National Preserve, Barstow, California, USA., Vu RK; California Department of Fish and Wildlife, Rancho Cordova, California, USA., Epps CW; Department of Fisheries, Wildlife, and Conservation Sciences, Oregon State University, Corvallis, Oregon, USA., Jolles AE; Department of Integrative Biology, Oregon State University, Corvallis, Oregon, USA.; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
المصدر:	The Journal of animal ecology [J Anim Ecol] 2023 Jul; Vol. 92 (7), pp. 1456-1469. Date of Electronic Publication: 2023 Jan 27.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة:	English
بيانات الدورية:	Publisher: Blackwell Country of Publication: England NLM ID: 0376574 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2656 (Electronic) Linking ISSN: 00218790 NLM ISO Abbreviation: J Anim Ecol Subsets: MEDLINE
أسماء مطبوعة:	Publication: Oxford : Blackwell Original Publication: Oxford, British Ecological Society.
مواضيع طبية MeSH:	Sheep, Bighorn* , Pneumonia/veterinary , Communicable Diseases , Sheep Diseases*/epidemiology, Animals ; Sheep ; Genetic Variation ; Immunity
مستخلص:	Habitat fragmentation is an important driver of biodiversity loss and can be remediated through management actions aimed at maintenance of natural connectivity in metapopulations. Connectivity may protect populations from infectious diseases by preserving immunogenetic diversity and disease resistance. However, connectivity could exacerbate the risk of infectious disease spread across vulnerable populations. We tracked the spread of a novel strain of Mycoplasma ovipneumoniae in a metapopulation of desert bighorn sheep Ovis canadensis nelsoni in the Mojave Desert to investigate how variation in connectivity among populations influenced disease outcomes. M. ovipneumoniae was detected throughout the metapopulation, indicating that the relative isolation of many of these populations did not protect them from pathogen invasion. However, we show that connectivity among bighorn sheep populations was correlated with higher immunogenetic diversity, a protective immune response and lower disease prevalence. Variation in protective immunity predicted infection risk in individual bighorn sheep and was associated with heterozygosity at genetic loci linked to adaptive and innate immune signalling. Together, these findings may indicate that population connectivity maintains immunogenetic diversity in bighorn sheep populations in this system and has direct effects on immune responses in individual bighorn sheep and their susceptibility to infection by a deadly pathogen. Our study suggests that the genetic benefits of population connectivity could outweigh the risk of infectious disease spread and supports conservation management that maintains natural connectivity in metapopulations. (© 2023 The Authors. Journal of Animal Ecology © 2023 British Ecological Society.)
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فهرسة مساهمة:	Keywords: bighorn; connectivity; disease ecology; ecoimmunology; genetic diversity; mycoplasma
سلسلة جزيئية:	Dryad 10.5061/dryad.5x69p8d2c
تواريخ الأحداث:	Date Created: 20230113 Date Completed: 20230706 Latest Revision: 20230718
رمز التحديث:	20231215
DOI:	10.1111/1365-2656.13885
PMID:	36637333
قاعدة البيانات:	MEDLINE

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تدمد:	1365-2656
DOI:	10.1111/1365-2656.13885