دورية أكاديمية
Evaluation of Safety and Efficacy of Intravenous Digoxin Loading Doses Based on Ideal Body Weight.
| العنوان: | Evaluation of Safety and Efficacy of Intravenous Digoxin Loading Doses Based on Ideal Body Weight. |
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| المؤلفون: | Clark JL; Department of Pharmacy, University of Utah Health, Salt Lake City, UT, USA.; Department of Pharmacy, University of Kentucky HealthCare, Lexington, KY, USA., Jacobs JA; Department of Pharmacy, University of Utah Health, Salt Lake City, UT, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA., Watanabe AH; College of Pharmacy, University of Utah, Salt Lake City, UT, USA., Catino AB; Department of Cardiology, University of Utah Health, Salt Lake City, UT, USA., Dechand JA; Department of Pharmacy, University of Utah Health, Salt Lake City, UT, USA. |
| المصدر: | The Annals of pharmacotherapy [Ann Pharmacother] 2023 Oct; Vol. 57 (10), pp. 1154-1161. Date of Electronic Publication: 2023 Jan 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 9203131 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-6270 (Electronic) Linking ISSN: 10600280 NLM ISO Abbreviation: Ann Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sept. 2013- : Thousand Oaks, CA : Sage Original Publication: Cincinnati, OH : Harvey Whitney Books Co., c1992- |
| مواضيع طبية MeSH: | Ideal Body Weight* , Digoxin*/adverse effects, Humans ; Retrospective Studies ; Body Weight |
| مستخلص: | Background: Intravenous digoxin loading dose recommendations differ between clinical guidelines and Food and Drug Administration packaging for acute rate control. Objective: The objective of this study was to assess the safety and efficacy of intravenous digoxin loading in patients who received ≤12 µg/kg and >12 µg/kg of digoxin using ideal body weight (IBW). Methods: This single center retrospective cohort study with exempt status from the local Institutional Review Board included patients who received intravenous digoxin and had a serum digoxin concentration (SDC) drawn. Digoxin doses >36 hours after the first dose were excluded. Patients who received a total of >12 µg/kg and ≤12 µg/kg IBW were compared. The primary endpoint was frequency of SDCs ≥1.2 ng/mL, which have been shown to be associated with increased mortality. Results: A total of 244 patients were included (144 receiving >12 µg/kg and 100 receiving ≤12 µg/kg). There were significantly more SDC ≥1.2 ng/mL in the >12 µg/kg group than the ≤12 µg/kg group (50.6% vs. 30.0%; adjusted odds ratio, 3.19; 95% confidence interval [CI]: 1.79-5.84), with no difference in rate control failure. Major limitations of the study include retrospective nature and possible selection bias. Conclusion and Relevance: Compared to patients who received digoxin doses ≤12 µg/kg IBW, patients who received >12 µg/kg IBW had higher rates of SDC ≥1.2 ng/mL. This suggests that appropriate weight-based dosing with 8 to 12 µg/kg IBW has the potential to be a safer approach to digoxin loading, rather than frequently used dosing strategies that result in doses >12 µg/kg. |
| فهرسة مساهمة: | Keywords: arrhythmias; digoxin; dose-response relationship; dosing; drug monitoring |
| المشرفين على المادة: | 73K4184T59 (Digoxin) |
| تواريخ الأحداث: | Date Created: 20230116 Date Completed: 20230922 Latest Revision: 20231013 |
| رمز التحديث: | 20231013 |
| DOI: | 10.1177/10600280221146530 |
| PMID: | 36642982 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1542-6270 |
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| DOI: | 10.1177/10600280221146530 |