دورية أكاديمية
أعرض في EDS

Predictive Score for Carbapenem-Resistant Gram-Negative Bacilli Sepsis: Single-Center Prospective Cohort Study.

التفاصيل البيبلوغرافية
العنوان: Predictive Score for Carbapenem-Resistant Gram-Negative Bacilli Sepsis: Single-Center Prospective Cohort Study.
المؤلفون: Gomes MZR; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil.; Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil.; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil.; Hospital Infection Control Committee, Hospital Universitário Pedro Ernesto, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil., Braga DQ; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil.; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Pinheiro DOBP; Hospital Infection Control Committee, Hospital Universitário Pedro Ernesto, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil., Verduc RCAS; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil.; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Dos Reis LV; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., de Lima EM; Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil.; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Lourenço ND; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Cid PA; Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Beck DS; Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Pinheiro LHZ; Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Tonhá JPS; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., de Sousa LS; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Dias MLS; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., da Silva Machado AA; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Castro MM; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Dutra VPR; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., de Mello LS; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., da Silva MC; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Tozo TM; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Mathuiy YR; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., de Abreu Rosas LLP; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Barros PCM; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., da Silva JO; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., da Silva PP; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., Bandeira CS; Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro 21040-900, Brazil., de Sant Anna Reis Di Chiara Salgado SM; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., de Oliveira Alves MZ; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Santos RQ; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Marques JA; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Rodrigues CAS; Hospital Federal dos Servidores do Estado (HFSE), Ministry of Health, Rio de Janeiro 20221-903, Brazil., Dos Santos Gomes Junior SC; Instituto Fernandes Figueira, Oswaldo Cruz Foundation, Rio de Janeiro 22250-020, Brazil.
مؤلفون مشاركون: Nucleus of Hospital Research Study Collaborators
المصدر: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2022 Dec 23; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2012-
مستخلص: A clinical-epidemiological score to predict CR-GNB sepsis to guide empirical antimicrobial therapy (EAT), using local data, persists as an unmet need. On the basis of a case-case-control design in a prospective cohort study, the predictive factors for CR-GNB sepsis were previously determined as prior infection, use of mechanical ventilation and carbapenem, and length of hospital stay. In this study, each factor was scored according to the logistic regression coefficients, and the ROC curve analysis determined its accuracy in predicting CR-GNB sepsis in the entire cohort. Among the total of 629 admissions followed by 7797 patient-days, 329 single or recurrent episodes of SIRS/sepsis were enrolled, from August 2015 to March 2017. At least one species of CR-GNB was identified as the etiology in 108 (33%) episodes, and 221 were classified as the control group. The cutoff point of ≥3 (maximum of 4) had the best sensitivity/specificity, while ≤1 showed excellent sensitivity to exclude CR-GNB sepsis. The area under the curve was 0.80 (95% CI: 0.76-0.85) and the number needed to treat was 2.0. The score may improve CR-GNB coverage and spare polymyxins with 22% (95% CI: 17-28%) adequacy rate change. The score has a good ability to predict CR-GNB sepsis and to guide EAT in the future.
References: Antimicrob Resist Infect Control. 2020 Aug 14;9(1):132. (PMID: 32795380)
Clin Microbiol Infect. 2021 Feb;27(2):228-235. (PMID: 33130270)
Emerg Infect Dis. 2011 Oct;17(10):1791-8. (PMID: 22000347)
Crit Care. 2008;12(2):R56. (PMID: 18426596)
Methods Mol Biol. 2015;1237:17-33. (PMID: 25319776)
J Biomed Inform. 2005 Oct;38(5):404-15. (PMID: 16198999)
J Microbiol Immunol Infect. 2017 Oct;50(5):677-683. (PMID: 26188977)
J Clin Epidemiol. 2016 Nov;79:22-28. (PMID: 27181564)
Intensive Care Med. 2021 Nov;47(11):1181-1247. (PMID: 34599691)
J Biomed Inform. 2019 Jul;95:103208. (PMID: 31078660)
Front Med (Lausanne). 2019 Apr 16;6:74. (PMID: 31041313)
Eur J Clin Microbiol Infect Dis. 2020 Feb;39(2):281-286. (PMID: 31654147)
Sci Rep. 2019 Sep 20;9(1):13663. (PMID: 31541157)
JAMA. 2016 Feb 23;315(8):762-74. (PMID: 26903335)
BMC Med. 2017 Jun 1;15(1):112. (PMID: 28571585)
Clin Infect Dis. 2019 Nov 13;69(Suppl 7):S565-S575. (PMID: 31724043)
Clin Infect Dis. 2019 Nov 13;69(Suppl 7):S521-S528. (PMID: 31724045)
JAMA. 2016 Feb 23;315(8):801-10. (PMID: 26903338)
Antimicrob Resist Infect Control. 2019 Jan 25;8:19. (PMID: 30701071)
Crit Care Med. 2003 Apr;31(4):1250-6. (PMID: 12682500)
Crit Care. 2021 Aug 26;25(1):307. (PMID: 34446092)
Braz J Infect Dis. 2017 Jan - Feb;21(1):98-101. (PMID: 27832961)
Antibiotics (Basel). 2021 Apr 10;10(4):. (PMID: 33920199)
Clin Infect Dis. 2001 Apr 1;32(7):1055-61. (PMID: 11264034)
Infect Drug Resist. 2018 Mar 01;11:283-293. (PMID: 29535544)
Eur J Clin Microbiol Infect Dis. 2019 Feb;38(2):383-393. (PMID: 30488368)
J Hosp Infect. 2019 Oct;103(2):121-127. (PMID: 31039381)
J Clin Epidemiol. 2008 Apr;61(4):344-9. (PMID: 18313558)
Antibiotics (Basel). 2020 Feb 09;9(2):. (PMID: 32050434)
Crit Care Med. 2013 Oct;41(10):2373-8. (PMID: 23921277)
Crit Care Med. 2006 Jun;34(6):1589-96. (PMID: 16625125)
Clin Microbiol Rev. 2019 Aug 28;32(4):. (PMID: 31462403)
Clin Microbiol Infect. 2017 Feb;23(2):104-109. (PMID: 27856268)
Eur J Intern Med. 2018 Jul;53:21-28. (PMID: 29426676)
فهرسة مساهمة: Keywords: Gram-negative bacteria; ROC curve; antibiotic resistance; cohort study; intensive care unit; risk scores; sepsis
تواريخ الأحداث: Date Created: 20230121 Latest Revision: 20240911
رمز التحديث: 20240911
مُعرف محوري في PubMed: PMC9854893
DOI: 10.3390/antibiotics12010021
PMID: 36671222
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-6382
DOI:10.3390/antibiotics12010021