دورية أكاديمية
Profiling the Spatial Expression Pattern and ceRNA Network of lncRNA, miRNA, and mRNA Associated with the Development of Intermuscular Bones in Zebrafish.
| العنوان: | Profiling the Spatial Expression Pattern and ceRNA Network of lncRNA, miRNA, and mRNA Associated with the Development of Intermuscular Bones in Zebrafish. |
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| المؤلفون: | Ye W; Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Shi M; Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China., Ren K; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China., Liu Y; College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China., Duan Y; Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Cheng Y; Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China., Zhang W; Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China., Xia XQ; Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing 100101, China. |
| المصدر: | Biology [Biology (Basel)] 2022 Dec 31; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101587988 Publication Model: Electronic Cited Medium: Print ISSN: 2079-7737 (Print) Linking ISSN: 20797737 NLM ISO Abbreviation: Biology (Basel) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, 2012- |
| مستخلص: | Intermuscular bones (IBs) are small spicule-like bones in the muscular septum of fish, which affect their edible and economic value. The molecular mechanism of IB development is still uncertain. Numerous studies have shown that the ceRNA network, which is composed of mRNA, lncRNA, and miRNA, plays an important regulatory role in bone development. In this study, we compared the mRNA, lncRNA, and miRNA expression profiles in different IB development segments of zebrafish. The development of IBs includes two main processes, which are formation and growth. A series of genes implicated in the formation and growth of IBs were identified through gene differential expression analysis and expression pattern analysis. Functional enrichment analysis showed that the functions of genes implicated in the regulation of the formation and growth of IBs were quite different. Ribosome and oxidative phosphorylation signaling pathways were significantly enriched during the formation of IBs, suggesting that many proteins are required to form IBs. Several pathways known to be associated with bone development have been shown to play an important role in the growth of IBs, including calcium, ECM-receptor interaction, Wnt, TGF-β, and hedgehog signaling pathways. According to the targeting relationship and expression correlation of mRNA, lncRNA, and miRNA, the ceRNA networks associated with the growth of IBs were constructed, which comprised 33 mRNAs, 9 lncRNAs, and 7 miRNAs. This study provides new insight into the molecular mechanism of the development of IBs. |
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| معلومات مُعتمدة: | 31801055 National Natural Science Foundation of China; 2021YFD1200804 National Key R&D Program of China; XDA24010206 Strate-gic Priority Research Program of the Chinese Academy of Sciences; 2018YFD0901201 National Key R&D Program of China |
| فهرسة مساهمة: | Keywords: ceRNA network; intramuscular bones; lncRNA; miRNA; zebrafish |
| تواريخ الأحداث: | Date Created: 20230121 Latest Revision: 20230201 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9855694 |
| DOI: | 10.3390/biology12010075 |
| PMID: | 36671767 |
| قاعدة البيانات: | MEDLINE |
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