دورية أكاديمية
Quantifying In-Host Quasispecies Evolution.
| العنوان: | Quantifying In-Host Quasispecies Evolution. |
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| المؤلفون: | Gregori J; Liver Diseases-Viral Hepatitis, Liver Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain., Ibañez-Lligoña M; Liver Diseases-Viral Hepatitis, Liver Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.; Biochemistry and Molecular Biology Department, Universitat Autònoma de Barcelona (UAB), Campus de la UAB, Plaça Cívica, 08193 Bellaterra, Spain., Quer J; Liver Diseases-Viral Hepatitis, Liver Unit, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.; Biochemistry and Molecular Biology Department, Universitat Autònoma de Barcelona (UAB), Campus de la UAB, Plaça Cívica, 08193 Bellaterra, Spain. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Jan 09; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Quasispecies*/genetics , Ecosystem*, Humans ; Evolution, Molecular |
| مستخلص: | What takes decades, centuries or millennia to happen with a natural ecosystem, it takes only days, weeks or months with a replicating viral quasispecies in a host, especially when under treatment. Some methods to quantify the evolution of a quasispecies are introduced and discussed, along with simple simulated examples to help in the interpretation and understanding of the results. The proposed methods treat the molecules in a quasispecies as individuals of competing species in an ecosystem, where the haplotypes are the competing species, and the ecosystem is the quasispecies in a host, and the evolution of the system is quantified by monitoring changes in haplotype frequencies. The correlation between the proposed indices is also discussed, and the R code used to generate the simulations, the data and the plots is provided. The virtues of the proposed indices are finally shown on a clinical case. |
| References: | Virology. 2018 Oct;523:100-109. (PMID: 30107298) BMC Infect Dis. 2018 Sep 3;18(1):446. (PMID: 30176817) Int J Mol Sci. 2022 Nov 24;23(23):. (PMID: 36498981) Bioinformatics. 2019 Feb 1;35(3):526-528. (PMID: 30016406) Virology. 2016 Jun;493:227-37. (PMID: 27060566) Infect Genet Evol. 2020 Aug;82:104277. (PMID: 32151775) |
| معلومات مُعتمدة: | IDI-20200297; Centre for Industrial Technological Development; GLD21/00006 Instituto de Salud Carlos III cofinanced by the European 332 Regional Development Fund (ERDF), and Gilead's biomedical research project |
| فهرسة مساهمة: | Keywords: distributions similarity; mutagenesis; quasispecies evolution; quasispecies fitness partition; viral treatment |
| تواريخ الأحداث: | Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20230202 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9867078 |
| DOI: | 10.3390/ijms24021301 |
| PMID: | 36674827 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1422-0067 |
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| DOI: | 10.3390/ijms24021301 |