دورية أكاديمية
أعرض في EDS

Evaluation of Antioxidant and Anticancer Activity of Mono- and Polyfloral Moroccan Bee Pollen by Characterizing Phenolic and Volatile Compounds.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Antioxidant and Anticancer Activity of Mono- and Polyfloral Moroccan Bee Pollen by Characterizing Phenolic and Volatile Compounds.
المؤلفون: Aylanc V; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal., Larbi S; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Département de Génies Biologique et Agroalimentaire, Université Libre de Tunis, 30 Avenue Kheireddine Pacha, Tunis 1002, Tunisia., Calhelha R; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal., Barros L; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal., Rezouga F; Département de Génies Biologique et Agroalimentaire, Université Libre de Tunis, 30 Avenue Kheireddine Pacha, Tunis 1002, Tunisia., Rodríguez-Flores MS; Facultad de Ciencias, Universidad de Vigo, Campus as Lagoas, 36310 Vigo, Pontevedra, Spain., Seijo MC; Facultad de Ciencias, Universidad de Vigo, Campus as Lagoas, 36310 Vigo, Pontevedra, Spain., El Ghouizi A; Laboratory Physiology-Pharmacology and Environmental Health, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez 30050, Morocco., Lyoussi B; Laboratory Physiology-Pharmacology and Environmental Health, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez 30050, Morocco., Falcão SI; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal., Vilas-Boas M; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 13; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Antioxidants*/chemistry , Flavonoids*/chemistry, Animals ; Bees ; Gas Chromatography-Mass Spectrometry ; Mass Spectrometry ; Phenols/chemistry ; Pollen/chemistry
مستخلص: Bee pollen is frequently characterized as a natural source of bioactive components, such as phenolic compounds, which are responsible for its pharmaceutical potential and nutritional properties. In this study, we evaluated the bioactive compound contents of mono- and polyfloral bee pollen samples using spectroscopic and chromatographic methods and established links with their antioxidant and antitumor activity. The findings demonstrated that the botanical origin of bee pollen has a remarkable impact on its phenolic (3-17 mg GAE/g) and flavonoid (0.5-3.2 mg QE/g) contents. Liquid chromatography-mass spectrometry analysis revealed the presence of 35 phenolic and 13 phenylamide compounds in bee pollen, while gas chromatography-mass spectrometry showed its richness in volatiles, such as hydrocarbons, fatty acids, alcohols, ketones, etc. The concentration of bioactive compounds in each sample resulted in a substantial distinction in their antioxidant activity, DPPH (EC 50 : 0.3-0.7 mg/mL), ABTS (0.8-1.3 mM Trolox/mg), and reducing power (0.03-0.05 mg GAE/g), with the most bioactive pollens being the monofloral samples from Olea europaea and Ononis spinosa . Complementarily, some samples revealed a moderate effect on cervical carcinoma (GI 50 : 495 μg/mL) and breast adenocarcinoma (GI 50 : 734 μg/mL) cell lines. This may be associated with compounds such as quercetin- O -diglucoside and kaempferol-3- O -rhamnoside, which are present in pollens from Olea europaea and Coriandrum , respectively. Overall, the results highlighted the potentiality of bee pollen to serve health-promoting formulations in the future.
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معلومات مُعتمدة: UIDB/00690/2020, UIDP/00690/2020 and LA/P/0007/2021 Fundação para a Ciência e Tecnologia; 2021.07764.BD for Volkan Aylanc, and contracts through the individual and institutional scientific employment program-contract for Lillian Barros, Soraia I. Falcão and Ricardo Calhelha Fundação para a Ciência e Tecnologia; PDR2020-1.0.1-FEADER-031734 Programa de Desenvolvimento Rural 2014-2020; Norte-01-0145-FEDER-000042 European Regional Development Fund
فهرسة مساهمة: Keywords: antiradical capacity; antitumor activity; bee products; bioactive compounds; phenolic compounds; phenylamides
المشرفين على المادة: 0 (Antioxidants)
0 (Flavonoids)
0 (Phenols)
تواريخ الأحداث: Date Created: 20230121 Date Completed: 20230124 Latest Revision: 20230124
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9866838
DOI: 10.3390/molecules28020835
PMID: 36677892
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28020835