دورية أكاديمية
أعرض في EDS

Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1.

التفاصيل البيبلوغرافية
العنوان: Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1.
المؤلفون: Islam S; Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh., Bhowmik DR; Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh., Roy S; Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh., Rahman Shuvo MS; Department of Microbiology, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh., Begum R; Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh., Hasan M; Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh., Amin MT; Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh., Ud Daula AS; Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh., Hossain MS; Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh.
المصدر: Heliyon [Heliyon] 2022 Dec 30; Vol. 9 (1), pp. e12737. Date of Electronic Publication: 2022 Dec 30 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Obesity is a severe public health burden and a major component of metabolic syndrome. It is critical to identify treatment medicines for obesity and associated inflammation. We examined the anti-obesity and anti-inflammatory properties of Musa acuminate seeds methanol extract in high-fat diet-induced obesity. Changes in body weight, Lee index, fat mass accumulation, serum cholesterol, and serum triglyceride were monitored. Alteration in the expression of PPARγ, GLUT4, and MCP-1 at the transcript level in adipose tissue was also studied. After tabulation of our data, a significant reduction (p < 0.05) was recorded for body weight gain, and fat mass accumulation followed by significant changes (p < 0.05) in serum cholesterol, and serum triglyceride levels by the extract. In agreement with the biochemical data, the extract was capable enough (p < 0.05) to reduce the mRNA expression of PPARγ, and MCP-1, confirming the ability of the extract to ameliorate the risk of obesity and obesity-associated inflammation. Moreover, an in-silico study showed the high binding affinity of the reported compounds from M. acuminate like Delphinidin, Umbelliferon with COX-2, PPARγ, and MCP-1, supporting the notion of the risk-reducing potential of M.acuminate for obesity and obesity mediated inflammatory.
Competing Interests: None.
(© 2022 The Authors.)
References: Inflammation. 2015 Apr;38(2):858-70. (PMID: 25139581)
Clin Chem. 2009 Apr;55(4):611-22. (PMID: 19246619)
Pflugers Arch. 2020 Sep;472(9):1273-1298. (PMID: 32591906)
Cholesterol. 2016;2016:9747412. (PMID: 28042480)
Prostaglandins Other Lipid Mediat. 2022 Oct;162:106664. (PMID: 35843503)
Asian-Australas J Anim Sci. 2016 Sep;29(9):1338-44. (PMID: 26954122)
Biochem Pharmacol. 2005 Aug 1;70(3):417-25. (PMID: 15963474)
BMC Public Health. 2015 Mar 21;15:279. (PMID: 25880751)
J Comput Chem. 2010 Jan 30;31(2):455-61. (PMID: 19499576)
Gene. 2012 Jul 10;502(2):138-41. (PMID: 22561694)
Am J Transl Res. 2017 May 15;9(5):2050-2064. (PMID: 28559960)
J Agric Food Chem. 2000 Mar;48(3):844-8. (PMID: 10725161)
Scientifica (Cairo). 2016;2016:8391398. (PMID: 27872791)
Prostaglandins Other Lipid Mediat. 2011 Apr;94(3-4):73-80. (PMID: 21237281)
Int J Food Sci. 2021 Jun 1;2021:6681687. (PMID: 34124236)
Obesity (Silver Spring). 2015 Jan;23(1):7-15. (PMID: 25469998)
Electrophoresis. 1997 Dec;18(15):2714-23. (PMID: 9504803)
Phytomedicine. 2013 Jul 15;20(10):805-12. (PMID: 23632084)
Clin Interv Aging. 2015 Mar 25;10:605-9. (PMID: 25848236)
Int J Mol Sci. 2019 May 13;20(9):. (PMID: 31085992)
J Food Sci. 2021 Sep;86(9):3778-3797. (PMID: 34337757)
Diabetes Metab Syndr Obes. 2016 Feb 26;9:37-46. (PMID: 27013897)
Biochimie. 2005 Jan;87(1):51-6. (PMID: 15733737)
Planta Med. 2015 Jul;81(10):771-83. (PMID: 26132857)
Lipids Health Dis. 2014 Feb 08;13:29. (PMID: 24507240)
J Cheminform. 2012 Aug 13;4(1):17. (PMID: 22889332)
J Clin Endocrinol Metab. 2015 Feb;100(2):342-62. (PMID: 25590212)
J Food Biochem. 2020 Mar;44(3):e13137. (PMID: 31899556)
Molecules. 2016 Oct 11;21(10):. (PMID: 27727194)
Dev Cell. 2019 Feb 25;48(4):491-505.e9. (PMID: 30612939)
Br J Nutr. 2011 Dec;106(12):1810-3. (PMID: 21736779)
Endocrinology. 2010 Mar;151(3):971-9. (PMID: 20056828)
J Food Sci. 2011 Nov-Dec;76(9):C1292-9. (PMID: 22416691)
فهرسة مساهمة: Keywords: Cholesterol; MCP-1; Musa acuminate; Obesity; PPARγ
تواريخ الأحداث: Date Created: 20230123 Latest Revision: 20230201
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9849961
DOI: 10.1016/j.heliyon.2022.e12737
PMID: 36685474
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2022.e12737