دورية أكاديمية
Predictive Factors for Unnecessary Axillary Dissection According to SLN Metastasis in T1, T2 Stage Breast Cancer.
| العنوان: | Predictive Factors for Unnecessary Axillary Dissection According to SLN Metastasis in T1, T2 Stage Breast Cancer. |
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| المؤلفون: | Benli S; Dept. of Surgery, Division of Surgical Oncology, Mersin University Medical Faculty, Ciftlikkoy Kampusu, 33343 Yenişehir, Mersin, Turkey., Aksoy SÖ; Dept. of Surgery, Division of Breast Surgery, 9 Eylul University Medical Faculty, Izmir, Turkey., Sevinç Aİ; Dept. of Surgery, Division of Breast Surgery, 9 Eylul University Medical Faculty, Izmir, Turkey., Durak MG; Dept. of Pathology, 9 Eylul University Medical Faculty, Izmir, Turkey., Baysan C; Dept. of Public Health, Division of Epidemiology, Ankara University Medical Faculty, Ankara, Turkey. |
| المصدر: | Indian journal of surgical oncology [Indian J Surg Oncol] 2022 Dec; Vol. 13 (4), pp. 817-823. Date of Electronic Publication: 2022 Jul 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer India Country of Publication: India NLM ID: 101532448 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0975-7651 (Print) Linking ISSN: 09757651 NLM ISO Abbreviation: Indian J Surg Oncol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: New Delhi : Springer India |
| مستخلص: | The axillary nodes' status is essential in determining the treatment algorithm according to complete clinical staging. Unnecessary axillary lymph node dissection (ALND) has been prevented after sentinel lymph node biopsy (SLNB) has occurred in current practice. However, approximately half of patients with positive SLNB do not have axillary metastatic lymph nodes. Our study aims to predict unnecessary ALND in patients with SLN metastases by evaluating the patients' clinicopathological data. In total, 221 patients with macrometastasis in SLNB who underwent completion ALND were evaluated retrospectively. Patients were divided into two groups: patients with metastases only in the sentinel lymph node and additional axillary lymph nodes. Univariate and multivariate logistic regression analyses were used to analyze the correlation between SLN metastasis and axillary lymph node metastasis; clinicopathological characteristics, including patient age, menopause status, tumor size and grade, receptor status proliferative marker status, and molecular subtypes of the tumor. In the evaluation of T1-2, cN0 breast cancer patients with SLNB in the form of macrometastasis, only SLNB metastasis was found in 118 (53.4%) patients. In 103 (46.6%) patients, additional axillary node metastasis was observed. The risk of additional nodal spread correlated with patient age older than fertility age (age of 49) ( p = 0.015, OR: 1.96, 95% CI: 1.14-3.39) and the number of increased metastatic sentinel nodes ( p < 0.001). In line with the data shown by our study, the rate of axillary metastases increases in patients over the age of fertility and as the number of metastatic SLNs increases. Competing Interests: Conflict of InterestThe authors declare no competing interests. (© The Author(s), under exclusive licence to Indian Association of Surgical Oncology 2022.) |
| References: | JAMA. 2017 Sep 12;318(10):918-926. (PMID: 28898379) Oncoscience. 2018 Aug 22;5(7-8):239-247. (PMID: 30234145) J Clin Oncol. 2009 Jun 10;27(17):2800-8. (PMID: 19349546) Eur J Breast Health. 2019 Oct 01;15(4):249-255. (PMID: 31620684) Arch Surg. 2001 Jun;136(6):688-92. (PMID: 11387010) Anticancer Res. 2018 Apr;38(4):2109-2117. (PMID: 29599329) Med Sci Monit. 2017 Aug 25;23:4102-4108. (PMID: 28839123) J Clin Oncol. 2000 Jul;18(13):2553-9. (PMID: 10893286) Breast J. 2015 Jan-Feb;21(1):3-12. (PMID: 25494903) Surg Oncol. 1993 Dec;2(6):335-9; discussion 340. (PMID: 8130940) World J Surg. 1989 Jan-Feb;13(1):25-30. (PMID: 2658349) J Breast Cancer. 2018 Sep;21(3):315-320. (PMID: 30275860) Eur J Breast Health. 2019 Apr 01;15(2):76-84. (PMID: 31001608) JAMA Oncol. 2018 Nov 1;4(11):1511-1516. (PMID: 30003237) J Int Med Res. 2018 Feb;46(2):828-835. (PMID: 29441833) Lancet Oncol. 2014 Nov;15(12):1303-10. (PMID: 25439688) Cancer. 1999 Oct 15;86(8):1511-9. (PMID: 10526280) Ann Surg. 2008 Jan;247(1):150-6. (PMID: 18156935) Breast. 2020 Feb;49:93-100. (PMID: 31783315) N Engl J Med. 2003 Aug 7;349(6):546-53. (PMID: 12904519) J Clin Oncol. 2011 Jul 1;29(19):2619-27. (PMID: 21606424) Cancer. 2000 Aug 1;89(3):574-81. (PMID: 10931456) Ann Surg. 1999 Nov;230(5):692-6. (PMID: 10561094) J Clin Oncol. 2007 Aug 20;25(24):3657-63. (PMID: 17485711) |
| فهرسة مساهمة: | Keywords: ACOSOG Z0011; ALND; Breast cancer; SLNB; T1 or T2 |
| تواريخ الأحداث: | Date Created: 20230123 Latest Revision: 20231202 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9845505 |
| DOI: | 10.1007/s13193-022-01580-0 |
| PMID: | 36687257 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 0975-7651 |
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| DOI: | 10.1007/s13193-022-01580-0 |