دورية أكاديمية
Lacticaseibacillus rhamnosus CA15 (DSM 33960) strain as a new driver in restoring the normal vaginal microbiota: A randomized, double-blind, placebo-controlled clinical trial.
| العنوان: | Lacticaseibacillus rhamnosus CA15 (DSM 33960) strain as a new driver in restoring the normal vaginal microbiota: A randomized, double-blind, placebo-controlled clinical trial. |
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| المؤلفون: | Rapisarda AMC; Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.; ProBioEtna SRL, Spin off of the University of Catania, Catania, Italy., Pino A; ProBioEtna SRL, Spin off of the University of Catania, Catania, Italy.; Department of Agricultural, Food and Environment, University of Catania, Catania, Italy.; CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, Catania, Italy., Grimaldi RL; Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy., Caggia C; ProBioEtna SRL, Spin off of the University of Catania, Catania, Italy.; Department of Agricultural, Food and Environment, University of Catania, Catania, Italy.; CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, Catania, Italy., Randazzo CL; ProBioEtna SRL, Spin off of the University of Catania, Catania, Italy.; Department of Agricultural, Food and Environment, University of Catania, Catania, Italy.; CERNUT, Interdepartmental Research Centre in Nutraceuticals and Health Products, University of Catania, Catania, Italy., Cianci A; Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy.; ProBioEtna SRL, Spin off of the University of Catania, Catania, Italy. |
| المصدر: | Frontiers in surgery [Front Surg] 2023 Jan 09; Vol. 9, pp. 1075612. Date of Electronic Publication: 2023 Jan 09 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101645127 Publication Model: eCollection Cited Medium: Print ISSN: 2296-875X (Print) Linking ISSN: 2296875X NLM ISO Abbreviation: Front Surg Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| مستخلص: | Probiotics play a key role in maintaining the health of the female reproductive tract, representing a promising alternative to safeguard or restore the homeostasis of the vaginal microbiota. The present randomized double-blind placebo-controlled study was performed to evaluate the ability of the potential probiotic Lacticaseibacillus rhamnosus CA15 (DSM 33960) strain, orally administrated, to balance the vaginal microbiota of women with vaginal dysbiosis. Sixty women, with signs and symptoms of vaginal dysbiosis, were recruited and randomly allocated to receive oral capsules containing the L. rhamnosus CA15 (DSM 33960) strain at 1.0 × 10 10 colony-forming units or placebo once daily for 10 days. Clinical and microbiological parameters were evaluated in three scheduled appointments: at baseline (T0), 10 days after the start of the treatment (T1), and 30 days after the end of the treatment (T2). In addition, the quality of life, through the WHO quality of life assessment questionnaire, was assessed at baseline (T0) and 30 days after the end of the treatment (T2). The probiotic was well tolerated and no side effects were reported. The oral consumption of the potential probiotic L. rhamnosus CA15 (DSM 33960) strain determined a significant improvement of both clinical signs and symptoms not only 10 days after the start of the treatment (T1) but also 30 days after the end of the treatment (T2). A significant reduction of potential pathogens and a concomitant increase of lactobacilli was revealed, by microbial count, at both T1 and T2 sampling times. In addition, the enhancement of the perceived physical health, social relations, and environment was reported. Differently, in placebo group clinical and microbiological parameters as well as quality of life remained almost unchanged. The potential probiotic L. rhamnosus CA15 (DSM 33960) strain could be a safe and effective approach to restore and maintain a balanced vaginal microbiota. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Rapisarda, Pino, Grimaldi, Caggia, Randazzo and Cianci.) |
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| فهرسة مساهمة: | Keywords: dysbiosis; lactobacilli; probiotics; quality of life; vaginal microbiota; women's health |
| تواريخ الأحداث: | Date Created: 20230126 Latest Revision: 20230202 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9869686 |
| DOI: | 10.3389/fsurg.2022.1075612 |
| PMID: | 36700035 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-875X |
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| DOI: | 10.3389/fsurg.2022.1075612 |