Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole.

التفاصيل البيبلوغرافية
العنوان:	Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole.
المؤلفون:	de Souza LCDSV; Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil., Reis NF; Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil., Alcântara LM; Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil., da Silveira Souto SRL; Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil., de Araújo Penna B; Laboratory of Gram Positive Cocos, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Santos RCS; Natural Products Technology Laboratory, Pharmacy Faculty, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Robbs BK; Nova Friburgo Health Institute, Department of Basic Science, Nova Friburgo, Rio de Janeiro, Brazil., Machado FP; Natural Products Technology Laboratory, Pharmacy Faculty, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Castro HC; Laboratory of Antibiotics, Biochemistry and Molecular Modeling, Institute of Biology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Machado RLD; Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil., Rocha L; Natural Products Technology Laboratory, Pharmacy Faculty, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., de Souza Baptista AR; Center for Microorganisms' Investigation, Department of Microbiology and Parasitology, Biomedical Institute, Federal Fluminense University, Niterói, Alameda Barros Terra, s/nº, CEP: 24020-150, Brazil. andrearegina@id.uff.br.
المصدر:	Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2023 Mar; Vol. 54 (1), pp. 579-586. Date of Electronic Publication: 2023 Jan 26.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2019- : Switzerland, AG : Springer International Publishing Original Publication: Rio de Janeiro, RJ, Brasil : Sociedade Brasileira de Microbiologia
مواضيع طبية MeSH:	Ocotea* , Sporothrix* , Sporotrichosis/microbiology , Fungicides, Industrial/pharmacology, Itraconazole/pharmacology ; Antifungal Agents/pharmacology ; Microbial Sensitivity Tests
مستخلص:	Sporothrix brasiliensis with low susceptibility isolates were described from the Brazilian zoonotic sporotrichosis hyperendemics. The aim of this work was to evaluate distinct fractions of Ocotea pulchella, Ocotea notata, Myrciaria floribunda, and Hypericum brasiliense plant extracts against itraconazole-sensitive and low susceptibility S. brasiliensis isolates. Crude extracts were tested against clinical isolates and the ATCC MYA4823 to determine the minimum inhibitory concentrations (MICs) and fungicidal or fungistatic activities (MFC). A high MICs and MFCs amplitude (1 - > 128 µg/mL) were obtained for seven extracts. The highest antimicrobial activities against sensitive S. brasiliensis were displayed by the ethyl acetate extracts of O. notata (MIC = 2-128 μg/mL) and M. floribunda (MIC = 1-8 μg/mL). A fungicidal effect was observed for all fraction extracts. Ocotea spp. and M. floribunda ethyl acetate extracts provide promising profiles against itraconazole-sensitive or low susceptibility S. brasiliensis. Future studies will determine if these extracts can contribute as alternative therapies to this neglected zoonosis. (© 2023. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
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معلومات مُعتمدة:	Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; E-26/010.001882/2014 Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; PQ-CNPq Conselho Nacional de Desenvolvimento Científico e Tecnológico; PIBIC-CNPq/UFF Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة:	Keywords: Antifungal activities; Ethyl acetate fractions; Myrciaria floribunda; Ocotea spp.; Sporothrix brasiliensis; Sporotrichosis
المشرفين على المادة:	304NUG5GF4 (Itraconazole) 0 (Antifungal Agents) 76845O8NMZ (ethyl acetate) 0 (Fungicides, Industrial)
SCR Organism:	Sporothrix brasiliensis
تواريخ الأحداث:	Date Created: 20230126 Date Completed: 20230224 Latest Revision: 20240305
رمز التحديث:	20240305
مُعرف محوري في PubMed:	PMC9944169
DOI:	10.1007/s42770-023-00904-8
PMID:	36701111
قاعدة البيانات:	MEDLINE

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تدمد:	1678-4405
DOI:	10.1007/s42770-023-00904-8