دورية أكاديمية
In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance.
| العنوان: | In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance. |
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| المؤلفون: | Kedzierski L; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.; Faculty of Veterinary and Agricultural Sciences, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Er Qi Tan A; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Jia Hui Foo I; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.; Faculty of Veterinary and Agricultural Sciences, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Narayanan D; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Moily N; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia., McQuilten HA; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia., Nicholson SE; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Fazakerley JK; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.; Faculty of Veterinary and Agricultural Sciences, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia. |
| المصدر: | Immunology and cell biology [Immunol Cell Biol] 2023 Apr; Vol. 101 (4), pp. 333-344. Date of Electronic Publication: 2023 Feb 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 8706300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1711 (Electronic) Linking ISSN: 08189641 NLM ISO Abbreviation: Immunol Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : [Hoboken, NJ] : Wiley Original Publication: [Adelaide, South Australia] : University of Adelaide, [c1987- |
| مواضيع طبية MeSH: | Cytokines*/immunology , Encephalitis*/immunology , Encephalitis*/virology , Suppressor of Cytokine Signaling Proteins*/genetics , Suppressor of Cytokine Signaling Proteins*/metabolism, Animals ; Mice ; Immunity ; Semliki forest virus ; Signal Transduction |
| مستخلص: | Central nervous system virus infections are a major cause of morbidity and mortality worldwide and a significant global public health concern. As in many tissues, inflammation and immune responses in the brain, despite their protective roles, can also be harmful. Control of brain inflammation is important in many neurological diseases from encephalitis to multiple sclerosis and neurogenerative disease. The suppressors of cytokine signaling (SOCS) proteins are a key mechanism controlling inflammatory and immune responses across all tissues including the brain. Using a mouse model system, we demonstrate that lack of SOCS4 results in changes in the pathogenesis and clinical outcome of a neurotropic virus infection. Relative to wild-type mice, SOCS4-deficient mice showed accelerated clearance of virus from the brain, lower levels of persisting viral RNA in the brain, increased neuroinflammation and more severe neuropathology. We conclude that, in the mouse brain, SOCS4 is a vital regulator of antiviral immunity that mediates the critical balance between immunopathology and virus persistence. (© 2023 The Authors. Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of the Australian and New Zealand Society for Immunology, Inc.) |
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| فهرسة مساهمة: | Keywords: Semliki Forest virus; brain immunology; encephalitis; suppressors of cytokine signaling |
| المشرفين على المادة: | 0 (Cytokines) 0 (Suppressor of Cytokine Signaling Proteins) 0 (SOCS4 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20230126 Date Completed: 20230407 Latest Revision: 20230505 |
| رمز التحديث: | 20230506 |
| DOI: | 10.1111/imcb.12625 |
| PMID: | 36702633 |
| قاعدة البيانات: | MEDLINE |
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