دورية أكاديمية
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Potential outbreak by herpesvirus in equines: detection, clinical, and genetic analysis of equid gammaherpesvirus 2 (EHV-2).

التفاصيل البيبلوغرافية
العنوان: Potential outbreak by herpesvirus in equines: detection, clinical, and genetic analysis of equid gammaherpesvirus 2 (EHV-2).
المؤلفون: de Almeida Campos AC; Department of Microbiology, Instituto de Ciências Biomédicas II da Universidade de São Paulo (ICB-II/USP), SP, 05508-000, São Paulo, Brazil. camposac@alumni.usp.br.; Clinical and Molecular Virology Research Team, Scientific Platform Pasteur-USP (SPPU), SP, 05508-020, São Paulo, Brazil. camposac@alumni.usp.br., Cicolo S; Department of Surgery, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo-USP, SP, 05508-270, São Paulo, Brazil., de Oliveira CM; Department of Microbiology, Instituto de Ciências Biomédicas II da Universidade de São Paulo (ICB-II/USP), SP, 05508-000, São Paulo, Brazil., Molina CV; Department of Microbiology, Instituto de Ciências Biomédicas II da Universidade de São Paulo (ICB-II/USP), SP, 05508-000, São Paulo, Brazil.; Clinical and Molecular Virology Research Team, Scientific Platform Pasteur-USP (SPPU), SP, 05508-020, São Paulo, Brazil., Navas-Suárez PE; Wildlife Comparative Pathology Laboratory-LAPCOM, Faculdade de Medicina Veterinária e Zootecnia da, Universidade de São Paulo-USP, SP, 05508-270, São Paulo, Brazil.; Wildlife Disease Association-WDA, Associate member, 66044-7065, Lawrence-KS, United States., Poltronieri Dos Santos T; Department of Internal Medicine, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo-USP, SP, 05508-270, São Paulo, Brazil., da Silveira VB; Department of Microbiology, Instituto de Ciências Biomédicas II da Universidade de São Paulo (ICB-II/USP), SP, 05508-000, São Paulo, Brazil., Barbosa CM; Department of Microbiology, Instituto de Ciências Biomédicas II da Universidade de São Paulo (ICB-II/USP), SP, 05508-000, São Paulo, Brazil., Baccarin RYA; Department of Internal Medicine, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo-USP, SP, 05508-270, São Paulo, Brazil., Durigon EL; Department of Microbiology, Instituto de Ciências Biomédicas II da Universidade de São Paulo (ICB-II/USP), SP, 05508-000, São Paulo, Brazil., Góes LGB; Department of Microbiology, Instituto de Ciências Biomédicas II da Universidade de São Paulo (ICB-II/USP), SP, 05508-000, São Paulo, Brazil.; Clinical and Molecular Virology Research Team, Scientific Platform Pasteur-USP (SPPU), SP, 05508-020, São Paulo, Brazil., Belli CB; Department of Internal Medicine, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo-USP, SP, 05508-270, São Paulo, Brazil. cbbelli@usp.br., Oliveira DBL; Department of Microbiology, Instituto de Ciências Biomédicas II da Universidade de São Paulo (ICB-II/USP), SP, 05508-000, São Paulo, Brazil.; Hospital Israelita Albert Einstein, HIAE, 05652-900, São Paulo, Brazil.
المصدر: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2023 Jun; Vol. 54 (2), pp. 1137-1143. Date of Electronic Publication: 2023 Jan 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2019- : Switzerland, AG : Springer International Publishing
Original Publication: Rio de Janeiro, RJ, Brasil : Sociedade Brasileira de Microbiologia
مواضيع طبية MeSH: Rhadinovirus* , Herpesviridae Infections*/epidemiology , Herpesviridae Infections*/veterinary , Abortion, Spontaneous*/epidemiology , Herpesvirus 1, Equid*/genetics , Horse Diseases*/epidemiology, Pregnancy ; Female ; Humans ; Animals ; Horses ; Disease Outbreaks/veterinary
مستخلص: Background: Equid herpesvirus (EHV) commonly affects horses causing neurologic and respiratory symptoms beside spontaneous abortions, meaning huge economic losses for equine industry worldwide. In foals, the virus can facilitate secondary infections by Rhodococcus equi, important in morbidity and mortality in equines. A total of five genotypes of EHV were previously described in Brazil including EHV-1, EHV-2, EHV-3, EHV-4, and EHV-5. EHV-2 genotype had only been previously described in Brazil in asymptomatic animals. We report the investigation of the dead of 11 foals in Middle-west region of Brazil showing respiratory and neurological symptoms, as well as several abortions in mares from the same farm.
Methods: Clinical and laboratory exams were performed in this case study. Lung, whole blood, serum, and plasma samples were analyzed by necroscopic and histopathologic techniques followed by molecular assays (conventional and qPCR and Sanger sequencing).
Results and Conclusion: Laboratory exams revealed neutrophilia leukocytosis. Necroscopic and histopathologic findings were suppurative bronchopneumonia and ulcerative enteritis. Molecular assays point to the absence of the bacteria Rhodococcus equi and other viruses (including other EHV). The presence of EHV-2 DNA was confirmed by sequencing in serum sample from one foal. This is the first confirmed outbreak of EHV-2 causing disease in Brazilian horses with confirmed presence of the virus, and which highlight the important role of EHV-2 in equine respiratory disease and spontaneous abortions in equid in Brazil.
(© 2022. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
التعليقات: Erratum in: Braz J Microbiol. 2023 Feb 10;:. (PMID: 36763303)
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معلومات مُعتمدة: FAPESP 2014/15090-8 Fundação de Amparo à Pesquisa do Estado de São Paulo; FAPESP 2018/18867-4 Fundação de Amparo à Pesquisa do Estado de São Paulo; FAPESP technical training schollarship 2018/05346-6 Fundação de Amparo à Pesquisa do Estado de São Paulo; FAPESP 2016/08727-5 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2020/01487-4 Fundação de Amparo à Pesquisa do Estado de São Paulo; 133013/2019-7 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 152365/2019-2 Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة: Keywords: Abortion; EHV-2; Foal; Herpesvirus; Horse; Neurological signs; Pneumonia
تواريخ الأحداث: Date Created: 20230127 Date Completed: 20230605 Latest Revision: 20240128
رمز التحديث: 20240128
مُعرف محوري في PubMed: PMC10234995
DOI: 10.1007/s42770-022-00890-3
PMID: 36705807
قاعدة البيانات: MEDLINE
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