دورية أكاديمية
Effects of exercise training on inflammatory, neurotrophic and immunological markers and neurotransmitters in people with depression: A systematic review and meta-analysis.
| العنوان: | Effects of exercise training on inflammatory, neurotrophic and immunological markers and neurotransmitters in people with depression: A systematic review and meta-analysis. |
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| المؤلفون: | da Cunha LL; Postgraduate Program of Physical Education, Universidade Federal de Pelotas, Pelotas, Brazil; Study Group of Neuroscience, Physical Activity and Exercise, Universidade Federal de Pelotas, Pelotas, Brazil., Feter N; Study Group of Neuroscience, Physical Activity and Exercise, Universidade Federal de Pelotas, Pelotas, Brazil; Postgraduate Program of Epidemiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: natanfeter@hotmail.com., Alt R; Study Group of Neuroscience, Physical Activity and Exercise, Universidade Federal de Pelotas, Pelotas, Brazil., Rombaldi AJ; Postgraduate Program of Physical Education, Universidade Federal de Pelotas, Pelotas, Brazil; Study Group of Neuroscience, Physical Activity and Exercise, Universidade Federal de Pelotas, Pelotas, Brazil. |
| المصدر: | Journal of affective disorders [J Affect Disord] 2023 Apr 01; Vol. 326, pp. 73-82. Date of Electronic Publication: 2023 Jan 26. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Depression*/drug therapy , Depressive Disorder, Major*/drug therapy, Adult ; Female ; Humans ; Male ; Brain-Derived Neurotrophic Factor ; Kynurenine ; Antidepressive Agents/therapeutic use ; Exercise ; Neurotransmitter Agents |
| مستخلص: | Background: Major depressive disorder is the most common type of mental disorder. The biological pathway by which exercise promotes its antidepressant effects remains uncleared. This study aimed to systematically review the chronic effect of exercise on blood biomarkers and its association with changes in depressive symptoms in adults with major depressive disorder. Methods: Randomized controlled trials (RCT) published until February 2020 were screened in seven databases. Studies were systematically reviewed by two independent reviewers. Random effect meta-analysis was performed and reported as standardized mean differences (SMD) and 95 % confidence interval (CI). The meta- analysis protocol was registered with PROSPERO (CRD42021221177). Results: From 3865 records, 12 studies (N = 757 participants, mean age [SD]: 43.0 [11.0], 66.2 % women) were included in this review. Exercise training resulted in superior increase in circulating BDNF (SMD: 0.44, 95%CI: 0.15, 0.73) and kynurenine (SMD: 0.29, 95%CI: 0.04, 0.54), and decrease depressive symptoms (SMD: -0.72, 95%CI: -1.08, -0.37) in adults with major depression disorder compared to control groups. Multivariate meta-regression analysis showed that improvements in circulating levels of BDNF, kynurenine and interleukyn-6 were associated with decreases in depressive symptoms. Limitations: Results were not stratified by the type of medication used by participants due to the lack of reporting of the included studies. Few studies provided data on other biomarkers (e.g., TNF-α and IL-10) besides BNDF and kynurenine. Conclusions: Antidepressant effect of exercise may be triggered by improved circulating levels of BNDF, kynurenine, and interleukine-6 in adults with major depressive disorder. Competing Interests: Declaration of competing interest All authors declare that they have no conflicts of interest. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: BDNF; Biomarkers; Depression; Exercise; Major depression disorder |
| المشرفين على المادة: | 0 (Brain-Derived Neurotrophic Factor) 343-65-7 (Kynurenine) 0 (Antidepressive Agents) 0 (Neurotransmitter Agents) |
| تواريخ الأحداث: | Date Created: 20230129 Date Completed: 20230223 Latest Revision: 20230418 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.jad.2023.01.086 |
| PMID: | 36709828 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2517 |
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| DOI: | 10.1016/j.jad.2023.01.086 |