دورية أكاديمية
أعرض في EDS

Identification of key immune-related genes in dilated cardiomyopathy using bioinformatics analysis.

التفاصيل البيبلوغرافية
العنوان: Identification of key immune-related genes in dilated cardiomyopathy using bioinformatics analysis.
المؤلفون: Li F; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, China., Du TY; Department of Critical Care Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China., Wu LD; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, China., Zhang L; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, China., Liu HH; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, China., Zhang ZY; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, China., Zhang J; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, China., Zhang ZY; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, China., Qian LL; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, China., Wang RX; Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299, Qingyang Road, Wuxi, 214023, China. ruxingw@aliyun.com., Hao JF; Department of Cardiopulmonary Rehabilitation, Wuxi Tongren Rehabilitation Hospital Affiliated to Nanjing Medical University, Wuxi, 214122, China. haojf89@163.com.
المصدر: Scientific reports [Sci Rep] 2023 Feb 01; Vol. 13 (1), pp. 1820. Date of Electronic Publication: 2023 Feb 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Gene Expression Profiling* , Cardiomyopathy, Dilated*/genetics , Cardiomyopathy, Dilated*/metabolism, Humans ; Myocardium/metabolism ; Computational Biology
مستخلص: Dilated cardiomyopathy (DCM) is characterized by the left ventricular dilatation and impaired myocardial systolic dysfunction with high mortality and morbidity. However, the underlying mechanisms remain elusive. We first identified the differentially expressed genes (DEGs) between the DCM and control group using two expression profiles from GSE3585 and GSE84796. Enrichment analysis was conducted to explore the potential mechanisms underlying DCM. A total of four algorithms, including key module of MCODE, degree, maximum neighborhood component (MNC), and maximal clique centrality (MCC), were used to identify the hub genes within Cytoscape. The correlation between hub genes and infiltrated immune cells was evaluated to determine potential immune-related genes. The expression analysis and diagnosis value analysis of potential immune-related genes were performed. Finally, the expression analysis with GSE57338 and relationship analysis with the comparative toxicogenomics database (CTD) were performed to identify the key immune-related genes in DCM. A total of 80 DEGs were screened for DCM. Enrichment analysis revealed that DEGs were involved in the immune-related pathological process. Immune infiltration analysis indicated a potentially abnormal immune response in DCM. Four up-regulated genes (COL1A2, COL3A1, CD53, and POSTN) were identified as potential immune-related genes. Finally, three genes (COL1A2, COL3A1, and POSTN) were determined as the key immune-related genes in DCM via expression analysis with a validation set (GSE57338) and relationship analysis with CTD. Our study suggested that the upregulated COL1A2, COL3A1, and POSTN might be the key immune-related genes for DCM. Further studies are needed to validate the underlying mechanisms.
(© 2023. The Author(s).)
التعليقات: Erratum in: Sci Rep. 2023 Feb 22;13(1):3096. (PMID: 36813831)
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المشرفين على المادة: 0 (Collagen Type I, alpha2 Subunit)
تواريخ الأحداث: Date Created: 20230201 Date Completed: 20230203 Latest Revision: 20230316
رمز التحديث: 20230320
مُعرف محوري في PubMed: PMC9892583
DOI: 10.1038/s41598-022-26277-w
PMID: 36725968
قاعدة البيانات: MEDLINE
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