دورية أكاديمية
Multi-target analysis of cytostatics in hospital effluents over a 9-month period.
| العنوان: | Multi-target analysis of cytostatics in hospital effluents over a 9-month period. |
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| المؤلفون: | Gouveia TIA; LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, 4200-465 Porto, Portugal; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal., Silva AMT; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; LSRE-LCM - Laboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal., Freire MG; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal., Sousa ACA; Comprehensive Health Research Centre (CHRC) and Department of Biology, School of Science and Technology, University of Évora, 7006-554 Évora, Portugal. Electronic address: acsousa@uevora.pt., Alves A; LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, 4200-465 Porto, Portugal; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal., Santos MSF; LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, 4200-465 Porto, Portugal; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address: mssantos@fe.up.pt. |
| المصدر: | Journal of hazardous materials [J Hazard Mater] 2023 Apr 15; Vol. 448, pp. 130883. Date of Electronic Publication: 2023 Jan 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, |
| مواضيع طبية MeSH: | Cytostatic Agents*/analysis , Water Pollutants, Chemical*/chemistry, Humans ; Flutamide ; Etoposide/analysis ; Mycophenolic Acid ; Solid Phase Extraction/methods ; Environmental Monitoring/methods ; Pharmaceutical Preparations |
| مستخلص: | The consumption of cytostatics, pharmaceuticals prescribed in chemotherapy, is increasing every year and worldwide, along with the incidence of cancer. The presence and the temporal evolution of cytostatics in wastewaters from a Portuguese hospital center was evaluated through a 9-month sampling campaign, comprising a total of one hundred and twenty-nine samples, collected from May 2019 to February 2020. Eleven cytostatics out of thirteen pharmaceuticals were studied, including flutamide, mycophenolate mofetil and mycophenolic acid, which have never been monitored before. Target analytes were extracted and quantified by solid-phase extraction coupled to liquid-chromatography-tandem mass spectrometry analysis; the method was fully validated. All pharmaceuticals were detected in at least one sample, bicalutamide being the one found with higher frequency (detected in all samples), followed by mycophenolic acid, which was also the compound detected at higher concentrations (up to 5340 ± 211 ng/L). Etoposide, classified as carcinogenic to humans, was detected in 60% of the samples at concentrations up to 142 ± 15 ng/L. The risk from exposure to cytostatics was estimated for aquatic organisms living in receiving bodies. Cyclophosphamide, doxorubicin, etoposide, flutamide, megestrol and mycophenolic acid are suspected to induce risk. Long-term and synergic effects should not be neglected, even for the cytostatics for which no risk was estimated. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anticancer drugs; Hazardous medicinal products; Hospital wastewaters; Mass spectrometry; Occurrence; Risk; Solid-phase extraction; Temporal trend; Toxicity |
| المشرفين على المادة: | 0 (Cytostatic Agents) 76W6J0943E (Flutamide) 6PLQ3CP4P3 (Etoposide) HU9DX48N0T (Mycophenolic Acid) 0 (Water Pollutants, Chemical) 0 (Pharmaceutical Preparations) |
| تواريخ الأحداث: | Date Created: 20230202 Date Completed: 20230301 Latest Revision: 20230307 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jhazmat.2023.130883 |
| PMID: | 36731320 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3336 |
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| DOI: | 10.1016/j.jhazmat.2023.130883 |