Challenging breast cancer through novel sulfonamide-pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis.

التفاصيل البيبلوغرافية
العنوان:	Challenging breast cancer through novel sulfonamide-pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis.
المؤلفون:	Zaher NH; Drug Radiation Research, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt., Elhazek RM; Drug Radiation Research, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt., Gouda AE; Pharmaceutical Research Department, Nawah Scientific, Cairo, Egypt., Khalil A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk City, Cairo, 11837, Egypt.; The Center for Drug Research & Development (CDRD), Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk City, Cairo, 11837, Egypt., Elgazzar MG; Drug Radiation Research, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.
المصدر:	Future medicinal chemistry [Future Med Chem] 2023 Jan; Vol. 15 (2), pp. 147-166. Date of Electronic Publication: 2023 Feb 10.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: London : Future Science, 2009-
مواضيع طبية MeSH:	Breast Neoplasms*/drug therapy, Female ; Humans ; Antigens, Neoplasm/metabolism ; Apoptosis ; Carbonic Anhydrase Inhibitors/pharmacology ; Carbonic Anhydrase Inhibitors/metabolism ; Carbonic Anhydrase IX/antagonists & inhibitors ; Molecular Structure ; Pyridines/pharmacology ; Structure-Activity Relationship ; Sulfonamides/pharmacology ; Tumor Microenvironment
مستخلص:	Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide-pyridine hybrids ( 2-12 ) were designed, synthesized and biologically evaluated for their potential use in targeting breast cancer. Methods & results: The para chloro derivative 7 reported the highest cytotoxic activity against the three breast cancer cell lines used. In addition, compound 7 was found to induce cell cycle arrest and autophagy as well as delaying wound healing. The IC 50 of compound 7 against carbonic anhydrase IX was 253 ± 12 nM using dorzolamide HCl as control. Conclusion: This study encourages us to expand the designed library, where more sulfonamide derivatives would be synthesized and studied for their structure-activity relationships.
فهرسة مساهمة:	Keywords: apoptosis; breast cancer; carbonic anhydrase; hypoxia; sulfonamides
المشرفين على المادة:	0 (Antigens, Neoplasm) 0 (Carbonic Anhydrase Inhibitors) EC 4.2.1.1 (Carbonic Anhydrase IX) 0 (Pyridines) 0 (Sulfonamides)
تواريخ الأحداث:	Date Created: 20230210 Date Completed: 20230311 Latest Revision: 20230313
رمز التحديث:	20240829
DOI:	10.4155/fmc-2022-0197
PMID:	36762576
قاعدة البيانات:	MEDLINE

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تدمد:	1756-8927
DOI:	10.4155/fmc-2022-0197