دورية أكاديمية
أعرض في EDS

The HUNT study: A population-based cohort for genetic research.

التفاصيل البيبلوغرافية
العنوان: The HUNT study: A population-based cohort for genetic research.
المؤلفون: Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway., Graham S; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Skogholt AH; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway., Løset M; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.; Department of Dermatology, Clinic of Orthopaedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Fritsche LG; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Wolford B; Department of Computational Medicine and Bioinformatics, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Zhou W; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nielsen JB; Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark., Holmen OL; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway., Gabrielsen ME; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway., Thomas L; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.; Department of Clinical and Molecular Medicine, NTNU Norwegian University of Science and Technology, Trondheim, Norway.; BioCore-Bioinformatics Core Facility, NTNU Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Bhatta L; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway., Rasheed H; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway., Zhang H; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Kang HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Hornsby W; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA., Moksnes MR; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway., Coward E; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway., Melbye M; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway., Giskeødegård GF; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway., Fenstad J; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway., Krokstad S; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway.; Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Næss M; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Langhammer A; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Abecasis GR; Regeneron Genetics Center, Tarrytown, NY 10591, USA., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway., Willer CJ; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
المصدر: Cell genomics [Cell Genom] 2022 Oct 12; Vol. 2 (10), pp. 100193. Date of Electronic Publication: 2022 Oct 12 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier, Inc., [2021]-
مستخلص: The Trøndelag Health Study (HUNT) is a population-based cohort of ∼229,000 individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway. Approximately 88,000 of these individuals have available genetic data from array genotyping. HUNT participants were recruited during four community-based recruitment waves and provided information on health-related behaviors, self-reported diagnoses, family history of disease, and underwent physical examinations. Linkage via the Norwegian personal identification number integrates digitized health care information from doctor visits and national health registries including death, cancer and prescription registries. Genome-wide association studies of HUNT participants have provided insights into the mechanism of cardiovascular, metabolic, osteoporotic, and liver-related diseases, among others. Unique features of this cohort that facilitate research include nearly 40 years of longitudinal follow-up in a motivated and well-educated population, family data, comprehensive phenotyping, and broad availability of DNA, RNA, urine, fecal, plasma, and serum samples.
Competing Interests: G.R.A. works for Regeneron Pharmaceuticals. C.J.W.’s spouse works for Regeneron Pharmaceuticals.
(© 2022 The Author(s).)
References: Nat Genet. 2016 Oct;48(10):1279-83. (PMID: 27548312)
Bioinformatics. 2022 Sep 15;38(18):4337-4343. (PMID: 35876838)
Nat Genet. 2016 Oct;48(10):1284-1287. (PMID: 27571263)
Science. 2019 Sep 27;365(6460):1396-1400. (PMID: 31604265)
Nat Genet. 2019 Mar;51(3):387-393. (PMID: 30804566)
Nat Commun. 2020 Jul 14;11(1):3519. (PMID: 32665587)
Am J Hum Genet. 2012 Nov 2;91(5):839-48. (PMID: 23103226)
Am J Hum Genet. 2018 Jan 4;102(1):103-115. (PMID: 29290336)
Commun Biol. 2022 Jun 16;5(1):591. (PMID: 35710628)
Nat Commun. 2020 Dec 18;11(1):6417. (PMID: 33339817)
Nature. 2020 Oct;586(7831):749-756. (PMID: 33087929)
Int J Epidemiol. 2013 Aug;42(4):968-77. (PMID: 22879362)
Nat Genet. 2020 Jun;52(6):634-639. (PMID: 32424355)
Nat Genet. 2014 Feb;46(2):200-4. (PMID: 24336170)
Circ Genom Precis Med. 2023 Feb;16(1):e003542. (PMID: 36580301)
Nat Genet. 2009 Nov;41(11):1199-206. (PMID: 19801982)
Genet Med. 2013 Jul;15(7):565-74. (PMID: 23788249)
Nat Genet. 2015 Mar;47(3):284-90. (PMID: 25642633)
Hum Mol Genet. 2014 Sep 1;23(17):4721-8. (PMID: 24728188)
Nat Genet. 2012 Sep;44(9):981-90. (PMID: 22885922)
Nat Genet. 2014 Apr;46(4):345-51. (PMID: 24633158)
Nat Commun. 2020 Oct 26;11(1):5404. (PMID: 33106479)
Nat Commun. 2019 Apr 23;10(1):1847. (PMID: 31015462)
Int J Epidemiol. 2003 Feb;32(1):1-22. (PMID: 12689998)
Bioinformatics. 2020 Jun 1;36(11):3439-3446. (PMID: 32196066)
Science. 2008 Feb 22;319(5866):1100-4. (PMID: 18292342)
Hum Mol Genet. 2021 Oct 13;30(21):2027-2039. (PMID: 33961016)
Gigascience. 2015 Feb 25;4:7. (PMID: 25722852)
Circ Genom Precis Med. 2019 Jan;12(1):e002335. (PMID: 30645169)
Nat Genet. 2014 Apr;46(4):409-15. (PMID: 24633160)
Nat Genet. 2013 Nov;45(11):1274-1283. (PMID: 24097068)
Nat Genet. 2018 Sep;50(9):1335-1341. (PMID: 30104761)
Nat Genet. 2021 Sep;53(9):1276-1282. (PMID: 34493870)
Nat Genet. 2018 Sep;50(9):1234-1239. (PMID: 30061737)
Nat Commun. 2021 Mar 30;12(1):1964. (PMID: 33785739)
Nat Protoc. 2014 Nov;9(11):2643-62. (PMID: 25321409)
Cell. 2021 Nov 24;184(24):6003-6005. (PMID: 34822786)
Int J Epidemiol. 2014 Apr;43(2):536-44. (PMID: 23382364)
Nature. 2012 Sep 6;489(7414):57-74. (PMID: 22955616)
Nature. 2021 Dec;600(7890):675-679. (PMID: 34887591)
Genet Epidemiol. 2017 Dec;41(8):744-755. (PMID: 28861891)
Nat Commun. 2019 Aug 13;10(1):3503. (PMID: 31409809)
Nat Commun. 2020 Oct 23;11(1):4093. (PMID: 33097703)
Nat Genet. 2022 Dec;54(12):1803-1815. (PMID: 36474045)
Nature. 2021 Dec;600(7889):472-477. (PMID: 34237774)
Int J Epidemiol. 2021 Nov 10;50(5):1569-1579. (PMID: 34151951)
Kidney Int. 2020 Feb;97(2):236-242. (PMID: 31980069)
Cell Genom. 2022 Oct 12;2(10):100192. (PMID: 36777996)
Nat Genet. 2016 Nov;48(11):1443-1448. (PMID: 27694958)
Tidsskr Nor Laegeforen. 1990 Jun 10;110(15):1973-7. (PMID: 2363169)
Nat Genet. 2017 Mar;49(3):325-331. (PMID: 28092683)
Genet Epidemiol. 2015 May;39(4):227-38. (PMID: 25740221)
Nat Genet. 2020 Dec;52(12):1303-1313. (PMID: 33199917)
Nat Genet. 2021 Jun;53(6):817-829. (PMID: 34002096)
Nature. 2021 Feb;590(7845):290-299. (PMID: 33568819)
Nature. 2015 Feb 12;518(7538):197-206. (PMID: 25673413)
Nat Commun. 2020 Aug 7;11(1):3981. (PMID: 32769997)
Circulation. 2020 Oct 27;142(17):1633-1646. (PMID: 32981348)
Nat Genet. 2019 Feb;51(2):237-244. (PMID: 30643251)
Hypertension. 2022 Jan;79(1):170-177. (PMID: 34784738)
Nat Commun. 2021 Jul 16;12(1):4350. (PMID: 34272381)
Int J Epidemiol. 2022 Jan 6;50(6):1995-2010. (PMID: 34999880)
معلومات مُعتمدة: T32 HG000040 United States HG NHGRI NIH HHS
فهرسة مساهمة: Keywords: big data; biobank; cardiovascular health; complex disease; electronic health records; genetic epidemiology; genetics; longitudinal; omics; public health
تواريخ الأحداث: Date Created: 20230213 Latest Revision: 20240912
رمز التحديث: 20240912
مُعرف محوري في PubMed: PMC9903730
DOI: 10.1016/j.xgen.2022.100193
PMID: 36777998
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-979X
DOI:10.1016/j.xgen.2022.100193