دورية أكاديمية
RHCE variant alleles and risk of alloimmunization in Brazilians.
| العنوان: | RHCE variant alleles and risk of alloimmunization in Brazilians. |
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| المؤلفون: | Arnoni CP; Technical and Scientific Department, Colsan-Associação Beneficente de Coleta de Sangue, Avenida Jandira 1260, Indianópolis-CEP 04080-006, São Paulo, SP, Brazil., Vendrame TAP; Technical and Scientific Department, Colsan- Associação Beneficente de Coleta de Sangue, São Paulo, SP, Brazil., Silva FS; Technical and Scientific Department, Colsan-Associação Beneficente de Coleta de Sangue, São Paulo, SP, Brazil., Cortez AJP; Medical Department, Colsan-Associação Beneficente de Coleta de Sangue, São Paulo, SP, Brazil., Latini FRM; Technical and Scientific Department, Colsan-Associação Beneficente de Coleta de Sangue, São Paulo, SP, Brazil., Castilho L; Hemocentro-Unicamp, Campinas, SP, Brazil. |
| المصدر: | Immunohematology [Immunohematology] 2022 Dec 28; Vol. 38 (4), pp. 123-129. Date of Electronic Publication: 2022 Dec 28 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Red Cross Country of Publication: United States NLM ID: 8806387 Publication Model: Electronic-Print Cited Medium: Print ISSN: 0894-203X (Print) Linking ISSN: 0894203X NLM ISO Abbreviation: Immunohematology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Washington, D.C.] : American Red Cross, [1984- |
| مواضيع طبية MeSH: | Anemia, Hemolytic, Autoimmune* , Anemia, Sickle Cell*/genetics , Anemia, Sickle Cell*/therapy, Humans ; Rh-Hr Blood-Group System/genetics ; Alleles ; Brazil ; Retrospective Studies ; Isoantibodies |
| مستخلص: | Variant RHCE alleles are found mainly in Afro-descendant individuals, as well as in patients with sickle cell disease (SCD). The most common variants are related to the RHCE*ce allele, which can generate partial e and c antigens. Although RHCE variant alleles have been extensively studied, defining their clinical significance is a difficult task. We evaluated the risk of RhCE alloimmunization as a consequence of partial antigens in patients with a positive phenotype transfused with red blood cell (RBC) units with the corresponding antigen. A retrospective study was performed with Brazilian patients, evaluating the number of antigen-positive transfused RBC units (incompatible due to partial antigen) in 27 patients with SCD carrying RHCE variant alleles who did not develop antibodies as well as evaluating the variants present in 12 patients with partial phenotype and correlated antibody (one patient with SCD and 11 patients with other pathologies). Two patients showed variant alleles with molecular changes that had not yet been described. Variant RHCE alleles were identified in a previous study using molecular methods. RHCE*ceVS.01 was the most frequent allele found among the patients without antibodies. Six patients with partial c antigen had a mean of 3.8 c+ RBC units transfused, and 10 patients with partial e antigen were exposed for a mean of 7.2 e+ RBC units. Among the variant alleles found in alloimmunized patients, the most frequent was RHCE*ceAR, which was found in five patients; the antibodies developed were anti-hr S and/or anti-c. Our results showed that RHCE*ceVS.01 is indeed the most frequent variant allele in our cohort of patients with SCD, but the partial antigens that were identified have low risk of alloimmunization. RHCE*ceAR is the most impactful variant in the Brazilian population with high risk of alloimmunization and clinically significant anti-hr S formation. (© 2022 C.P. Arnoni et al., published by Sciendo.) |
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| فهرسة مساهمة: | Keywords: RHCE alleles; alloimmunization; partial antigens; sickle cell disease |
| المشرفين على المادة: | 0 (Rh-Hr Blood-Group System) 0 (Isoantibodies) 0 (RHCE protein, human) |
| تواريخ الأحداث: | Date Created: 20230215 Date Completed: 20230216 Latest Revision: 20230216 |
| رمز التحديث: | 20230216 |
| DOI: | 10.21307/immunohematology-2022-054 |
| PMID: | 36789463 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0894-203X |
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| DOI: | 10.21307/immunohematology-2022-054 |