دورية أكاديمية
Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia.
| العنوان: | Epidemiological serosurvey of chikungunya fever post outbreak at Tanjung Sepat, Malaysia. |
|---|---|
| المؤلفون: | Khor CS; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Teoh BT; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Sam SS; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Khoo HY; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Azizan NS; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., CheMatSeri A; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Chin KL; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Hamim ZR; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Mohamed-Romai-Noor NA; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Yaacob CN; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Abd-Jamil J; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Lee HY; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., Soh YH; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia., AbuBakar S; Tropical Infectious Diseases Research and Education Centre (TIDREC), Universiti Malaya, Kuala Lumpur, Malaysia. |
| المصدر: | Journal of infection in developing countries [J Infect Dev Ctries] 2023 Jan 31; Vol. 17 (1), pp. 118-124. Date of Electronic Publication: 2023 Jan 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Italy?] : Open Learning on Enteric Pathogens |
| مواضيع طبية MeSH: | Chikungunya Fever*/epidemiology , Chikungunya Fever*/complications , Chikungunya Fever*/diagnosis , Chikungunya virus*, Adult ; Animals ; Humans ; Malaysia/epidemiology ; Cross-Sectional Studies ; Antibodies, Viral ; Disease Outbreaks ; Asymptomatic Infections/epidemiology ; Seroepidemiologic Studies ; Immunoglobulin M |
| مستخلص: | Introduction: Chikungunya fever is a mosquito-borne viral disease that usually presents with prominent arthralgia. An outbreak of chikungunya fever was reported in Tanjung Sepat, Malaysia in 2019. The outbreak was limited in size with a low number of cases being reported. The present study sought to determine the possible variables that could have affected the transmission of the infection. Methodology: A cross-sectional study involving 149 healthy adult volunteers from Tanjung Sepat was performed soon after the outbreak had subsided. All the participants donated blood samples and completed the questionnaires. Laboratory detection of anti-CHIKV IgM and IgG antibodies was performed using enzyme-linked immunoassays (ELISA). Risk factors associated with chikungunya seropositivity were determined using logistic regression. Results: The majority (72.5%, n = 108) of the study participants tested positive for CHIKV antibodies. Only 8.3% (n = 9) of the participants out of all the seropositive volunteers had an asymptomatic infection. Participants who resided with a febrile (p < 0.05, Exp(B) = 2.2, confidence interval [CI] 1.3-3.6) or a CHIKV-diagnosed person (p < 0.05, Exp(B) = 2.1, CI 1.2-3.6) in the same household were found likely to be tested positive for CHIKV antibodies. Conclusions: Findings from the study support that asymptomatic CHIKV infections and indoor transmission occurred during the outbreak. Hence, widespread community testing and indoor use of mosquito repellent are among the possible measures that can be implemented to reduce CHIKV transmission during an outbreak. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2023 Chee-Sieng Khor, Boon-Teong Teoh, Sing-Sin Sam, Hooi-Yuen Khoo, Noor-Syahida Azizan, AsmaAnati CheMatSeri, Kim-Ling Chin, Zur-Raiha Hamim, Noor-Adila Mohamed-Romai-Noor, Che-Norainon Yaacob, Juraina Abd-Jamil, Hai-Yen Lee, Yih-Harng Soh, Sazaly AbuBakar.) |
| فهرسة مساهمة: | Keywords: Malaysia; asymptomatic; chikungunya; infectious diseases; seroprevalence; vector-borne |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Immunoglobulin M) |
| تواريخ الأحداث: | Date Created: 20230216 Date Completed: 20230222 Latest Revision: 20230228 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3855/jidc.16613 |
| PMID: | 36795935 |
| قاعدة البيانات: | MEDLINE |
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