Ketamine evoked disruption of entorhinal and hippocampal spatial maps.
| العنوان: | Ketamine evoked disruption of entorhinal and hippocampal spatial maps. |
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| المؤلفون: | Masuda FK; Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA., Sun Y; Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA., Aery Jones EA; Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA., Giocomo LM; Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 06. Date of Electronic Publication: 2023 Feb 06. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Ketamine, a rapid-acting anesthetic and acute antidepressant, carries undesirable spatial cognition side effects including out-of-body experiences and spatial memory impairments. The neural substrates that underlie these alterations in spatial cognition however, remain incompletely understood. Here, we used electrophysiology and calcium imaging to examine ketamine's impacts on the medial entorhinal cortex and hippocampus, which contain neurons that encode an animal's spatial position, as mice navigated virtual reality and real world environments. Ketamine induced an acute disruption and long-term re-organization of entorhinal spatial representations. This acute ketamine-induced disruption reflected increased excitatory neuron firing rates and degradation of cell-pair temporal firing rate relationships. In the reciprocally connected hippocampus, the activity of neurons that encode the position of the animal was suppressed after ketamine administration. Together, these findings point to disruption in the spatial coding properties of the entorhinal-hippocampal circuit as a potential neural substrate for ketamine-induced changes in spatial cognition. |
| التعليقات: | Update in: Nat Commun. 2023 Oct 7;14(1):6285. (PMID: 37805575) |
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| معلومات مُعتمدة: | T32 GM007365 United States GM NIGMS NIH HHS; T32 GM145402 United States GM NIGMS NIH HHS; P50 DA042012 United States DA NIDA NIH HHS; R01 MH126904 United States MH NIMH NIH HHS; U19 NS118284 United States NS NINDS NIH HHS; R01 MH130452 United States MH NIMH NIH HHS |
| تواريخ الأحداث: | Date Created: 20230217 Latest Revision: 20231118 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9934572 |
| DOI: | 10.1101/2023.02.05.527227 |
| PMID: | 36798242 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2023.02.05.527227 |
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