دورية أكاديمية
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells.
| العنوان: | β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells. |
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| المؤلفون: | Zhang Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Mao H; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Li Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Xiong Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Liu X; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Wang L; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Chen Z; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Beta-Cryptoxanthin*/pharmacology , NF-E2-Related Factor 2*/metabolism , Oxidative Stress*/drug effects , Cellular Senescence*/drug effects, Humans ; Hydrogen Peroxide/metabolism ; Mitochondria/metabolism ; Reactive Oxygen Species/metabolism ; Cell Line |
| مستخلص: | The mechanisms of acute kidney injury and chronic kidney disease remain incompletely revealed, and drug development is a pressing clinical challenge. Oxidative stress-induced cellular senescence and mitochondrial damage are important biological events in a variety of kidney diseases. As a type of carotenoid, β-Cryptoxanthin (BCX) has various biological functions, which means it is a potential therapeutic candidate for the treatment of kidney disease. However, the role of BCX in the kidney is unclear, and the effect of BCX on oxidative stress and cellular senescence in renal cells is also unknown. Therefore, we conducted a series of studies on human renal tubular epithelial (HK-2) cells in vitro. In the present study, we investigated the effect of BCX pretreatment on H |
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| معلومات مُعتمدة: | 82000639 National Natural Science Foundation of China |
| فهرسة مساهمة: | Keywords: HK-2 cells; NRF2; oxidative stress; senescence; β-Cryptoxanthin |
| المشرفين على المادة: | 0 (Beta-Cryptoxanthin) BBX060AN9V (Hydrogen Peroxide) 0 (NF-E2-Related Factor 2) 0 (Reactive Oxygen Species) |
| تواريخ الأحداث: | Date Created: 20230225 Date Completed: 20230324 Latest Revision: 20230324 |
| رمز التحديث: | 20230327 |
| مُعرف محوري في PubMed: | PMC9963668 |
| DOI: | 10.3390/ijms24043851 |
| PMID: | 36835262 |
| قاعدة البيانات: | MEDLINE |
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