دورية أكاديمية
β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells.
العنوان: | β-Cryptoxanthin Maintains Mitochondrial Function by Promoting NRF2 Nuclear Translocation to Inhibit Oxidative Stress-Induced Senescence in HK-2 Cells. |
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المؤلفون: | Zhang Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Mao H; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Li Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Xiong Y; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Liu X; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Wang L; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China., Chen Z; Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Beta-Cryptoxanthin*/pharmacology , NF-E2-Related Factor 2*/metabolism , Oxidative Stress*/drug effects , Cellular Senescence*/drug effects, Humans ; Hydrogen Peroxide/metabolism ; Mitochondria/metabolism ; Reactive Oxygen Species/metabolism ; Cell Line |
مستخلص: | The mechanisms of acute kidney injury and chronic kidney disease remain incompletely revealed, and drug development is a pressing clinical challenge. Oxidative stress-induced cellular senescence and mitochondrial damage are important biological events in a variety of kidney diseases. As a type of carotenoid, β-Cryptoxanthin (BCX) has various biological functions, which means it is a potential therapeutic candidate for the treatment of kidney disease. However, the role of BCX in the kidney is unclear, and the effect of BCX on oxidative stress and cellular senescence in renal cells is also unknown. Therefore, we conducted a series of studies on human renal tubular epithelial (HK-2) cells in vitro. In the present study, we investigated the effect of BCX pretreatment on H |
References: | Nutrients. 2020 Jul 22;12(8):. (PMID: 32708051) J Biomed Sci. 2012 Apr 02;19:36. (PMID: 22471523) Antioxid Redox Signal. 2016 Jul 20;25(3):117-8. (PMID: 27349471) Pediatr Nephrol. 2019 Jun;34(6):975-991. (PMID: 30105414) Redox Biol. 2019 Jun;24:101195. (PMID: 31004990) Cells. 2020 May 28;9(6):. (PMID: 32481548) J Biol Chem. 2008 Apr 4;283(14):8984-94. (PMID: 18238777) Biomed Pharmacother. 2018 Dec;108:656-662. (PMID: 30245465) Neoplasia. 2017 Oct;19(10):781-790. (PMID: 28865301) Oxid Med Cell Longev. 2022 Jan 28;2022:7444430. (PMID: 35126819) Exp Mol Med. 2022 Feb;54(2):115-128. (PMID: 35136202) Antioxidants (Basel). 2022 Sep 14;11(9):. (PMID: 36139884) Nutr Rev. 2016 Feb;74(2):69-82. (PMID: 26747887) Toxicol Appl Pharmacol. 2018 Nov 15;359:24-33. (PMID: 30236989) Curr Pharm Des. 2018;24(40):4794-4799. (PMID: 30648504) Int J Mol Sci. 2021 Mar 18;22(6):. (PMID: 33803589) Arch Physiol Biochem. 2022 Aug;128(4):1128-1135. (PMID: 32362203) Redox Biol. 2019 Sep;26:101254. (PMID: 31229841) Mol Cell Biochem. 2021 Jan;476(1):247-259. (PMID: 32918185) Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov;1865(11):158652. (PMID: 32035228) Semin Nephrol. 2019 May;39(3):308-314. (PMID: 31054631) Food Chem Toxicol. 2017 Sep;107(Pt A):270-279. (PMID: 28689061) Antioxid Redox Signal. 2014 Jan 1;20(1):74-101. (PMID: 23472618) Biochim Biophys Acta Mol Basis Dis. 2020 Dec 1;1866(12):165956. (PMID: 32877751) Genes Dev. 2014 Jan 15;28(2):99-114. (PMID: 24449267) Int J Mol Sci. 2020 Apr 22;21(8):. (PMID: 32331329) Annu Rev Pharmacol Toxicol. 2013;53:401-26. (PMID: 23294312) Int J Mol Sci. 2021 Jul 07;22(14):. (PMID: 34298945) Nat Rev Nephrol. 2014 Apr;10(4):193-207. (PMID: 24445744) Aging Cell. 2019 Jun;18(3):e12951. (PMID: 30907059) Neurol Sci. 2019 Feb;40(2):243-251. (PMID: 30523548) Mol Nutr Food Res. 2017 Oct;61(10):. (PMID: 28544535) J Cell Physiol. 2020 Apr;235(4):3119-3130. (PMID: 31549397) Aging (Albany NY). 2018 Jan 11;10(1):83-99. (PMID: 29326403) Front Immunol. 2021 Apr 15;12:637753. (PMID: 33936050) Biomolecules. 2021 Aug 03;11(8):. (PMID: 34439810) Antioxidants (Basel). 2022 Sep 30;11(10):. (PMID: 36290689) Front Physiol. 2021 Mar 23;12:649547. (PMID: 33833691) Oxid Med Cell Longev. 2020 Nov 23;2020:7627934. (PMID: 33299530) Diabetes Obes Metab. 2021 Nov;23(11):2561-2571. (PMID: 34318973) Oxid Med Cell Longev. 2022 Sep 20;2022:2213503. (PMID: 36193071) Physiol Rev. 2019 Apr 1;99(2):1047-1078. (PMID: 30648461) Redox Biol. 2015;4:180-3. (PMID: 25588755) Curr Atheroscler Rep. 2017 Sep 18;19(11):42. (PMID: 28921056) FASEB J. 2021 Jan;35(1):e21229. (PMID: 33368613) Curr Opin Nephrol Hypertens. 2022 May 1;31(3):235-243. (PMID: 35142744) |
معلومات مُعتمدة: | 82000639 National Natural Science Foundation of China |
فهرسة مساهمة: | Keywords: HK-2 cells; NRF2; oxidative stress; senescence; β-Cryptoxanthin |
المشرفين على المادة: | 0 (Beta-Cryptoxanthin) BBX060AN9V (Hydrogen Peroxide) 0 (NF-E2-Related Factor 2) 0 (Reactive Oxygen Species) |
تواريخ الأحداث: | Date Created: 20230225 Date Completed: 20230324 Latest Revision: 20230324 |
رمز التحديث: | 20230327 |
مُعرف محوري في PubMed: | PMC9963668 |
DOI: | 10.3390/ijms24043851 |
PMID: | 36835262 |
قاعدة البيانات: | MEDLINE |
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