دورية أكاديمية
Population-wide genetic analysis of Ovar-DQA1 and DQA2 loci across sheep breeds in India revealed their evolutionary importance and fitness of sheep in a tropical climate.
| العنوان: | Population-wide genetic analysis of Ovar-DQA1 and DQA2 loci across sheep breeds in India revealed their evolutionary importance and fitness of sheep in a tropical climate. |
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| المؤلفون: | Gowane GR; Animal Genetics and Breeding Division, ICAR-National Dairy Research Institute, Karnal, India., Sharma P; Animal Genetics and Breeding Division, ICAR-National Dairy Research Institute, Karnal, India., Kumar R; Animal Genetics and Breeding Division, ICAR-Central Sheep and Wool Research Institute, Avikanagar., Misra SS; Animal Genetics and Breeding Division, ICAR-Central Sheep and Wool Research Institute, Avikanagar., Alex R; Animal Genetics and Breeding Division, ICAR-National Dairy Research Institute, Karnal, India., Vohra V; Animal Genetics and Breeding Division, ICAR-National Dairy Research Institute, Karnal, India., Chhotaray S; Animal Genetics and Breeding Division, ICAR-National Dairy Research Institute, Karnal, India., Sharma N; Animal Health Section, ICAR-Central Institute for Research on Goats, Makhdoom, India., Chopra A; Animal Genetics and Breeding Division, ICAR-Arid Region Campus, Central Sheep and Wool Research Institute, Bikaner, India., Kandalkar Y; Deccani Sheep Breeding Unit, NWPSI at Mahatma Phule Krishi Vidyapith, Rahuri, India., Choudhary A; Central Sheep Breeding Farm, Hissar, India., Magotra A; Animal Genetics and Breeding Division, Chaudhary Charan Singh Haryana Agricultural University, Hisar, India. |
| المصدر: | Animal biotechnology [Anim Biotechnol] 2023 Dec; Vol. 34 (9), pp. 4645-4657. Date of Electronic Publication: 2023 Feb 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9011409 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2378 (Electronic) Linking ISSN: 10495398 NLM ISO Abbreviation: Anim Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Abingdon, Oxford : Taylor & Francis Original Publication: New York, N.Y. : Marcel Dekker, c1990- |
| مواضيع طبية MeSH: | Tropical Climate* , Histocompatibility Antigens Class II*/genetics, Sheep/genetics ; Animals ; Amino Acid Sequence ; India ; Alleles ; Genetic Variation/genetics ; Genes, MHC Class II |
| مستخلص: | Genetic variability at the major histocompatibility complex (MHC) is important in any species due to significant role played by MHC for antigen presentation. DQA locus has not been studied for its genetic variability across sheep population in India. In the present study, MHC of sheep at DQA1 and DQA2 loci were evaluated across 17 Indian sheep breeds. Results revealed high degree of heterozygosity (10.34% to 100% for DQA1 and 37.39 to 100% for DQA2). 18 DQA1 alleles and 22 DQA2 alleles were isolated in different breeds. Nucleotide content for DQA region revealed richness of AT content (54.85% for DQA1 and 53.89% for DQA2). DQA1 and DQA2 sequences clustered independently. We could see evidence of divergence of DQA as DQA1 and DQA2 across sheep breeds. Wu-Kabat variability index revealed vast genetic variation across DQA1 and DQA2, specifically at peptide binding sites (PBS) that consisted 21 residues for DQA1 and 17 residues for DQA2. Evolutionary analysis revealed the presence of positive and balancing selection for DQA1 locus, however DQA2 was under purifying selection across sheep breeds. Higher heterozygosity and large diversity at both loci especially at PBS indicated the fitness of the sheep population for evading pathogens and adapt to the harsh tropical climate. |
| فهرسة مساهمة: | Keywords: DQA divergence; Indian sheep; Wu-Kabat index; peptide binding sites; polymorphism |
| المشرفين على المادة: | 0 (Histocompatibility Antigens Class II) |
| تواريخ الأحداث: | Date Created: 20230227 Date Completed: 20240214 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| DOI: | 10.1080/10495398.2023.2180010 |
| PMID: | 36847639 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2378 |
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| DOI: | 10.1080/10495398.2023.2180010 |