دورية أكاديمية
Association of qacA/B and smr Carriage with Staphylococcus aureus Survival following Exposure to Antiseptics in an Ex Vivo Venous Catheter Disinfection Model.
العنوان: | Association of qacA/B and smr Carriage with Staphylococcus aureus Survival following Exposure to Antiseptics in an Ex Vivo Venous Catheter Disinfection Model. |
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المؤلفون: | McNeil JC; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Hospital, Houston, Texas, USA., Sommer LM; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Hospital, Houston, Texas, USA., Vallejo JG; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Hospital, Houston, Texas, USA., Hulten KG; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Hospital, Houston, Texas, USA., Kaplan SL; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.; Texas Children's Hospital, Houston, Texas, USA. |
المصدر: | Microbiology spectrum [Microbiol Spectr] 2023 Mar 02, pp. e0333322. Date of Electronic Publication: 2023 Mar 02. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : ASM Press, 2013- |
مستخلص: | Many health care centers have reported an association between Staphylococcus aureus isolates bearing efflux pump genes and an elevated MIC/minimal bactericidal concentration (MBC) to chlorhexidine gluconate (CHG) and other antiseptics. The significance of these organisms is uncertain, given that their MIC/MBC is typically far lower than the CHG concentration in most commercial preparations. We sought to evaluate the relationship between carriage of the efflux pump genes qacA/B and smr in S. aureus and the efficacy of CHG-based antisepsis in a venous catheter disinfection model. S. aureus isolates with and without smr and/or qacA/B were utilized. The CHG MICs were determined. Venous catheter hubs were inoculated and exposed to CHG, isopropanol, and CHG-isopropanol combinations. The microbiocidal effect was calculated as the percent reduction in CFU following exposure to the antiseptic relative to the control. The qacA/B- and smr -positive isolates had modest elevations in the CHG MIC |
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معلومات مُعتمدة: | K23 AI099159 United States AI NIAID NIH HHS; R01 HS026896 United States HS AHRQ HHS |
فهرسة مساهمة: | Keywords: Staphylococcus aureus; chlorhexidine gluconate; disinfection; pediatric; qacA/B; smr |
تواريخ الأحداث: | Date Created: 20230302 Latest Revision: 20240216 |
رمز التحديث: | 20240216 |
مُعرف محوري في PubMed: | PMC10100659 |
DOI: | 10.1128/spectrum.03333-22 |
PMID: | 36862001 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2165-0497 |
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DOI: | 10.1128/spectrum.03333-22 |