دورية أكاديمية
Choosing the source of healthy controls for studies on myeloid malignancies: all bone marrow cells are created equal, but some are more equal than others.
العنوان: | Choosing the source of healthy controls for studies on myeloid malignancies: all bone marrow cells are created equal, but some are more equal than others. |
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المؤلفون: | Rivière J; Department of Medicine III, School of Medicine, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany., Hock J; Department of Medicine III, School of Medicine, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany., Buck MC; Department of Medicine III, School of Medicine, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany., Hecker JS; Department of Medicine III, School of Medicine, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany., Götze KS; Department of Medicine III, School of Medicine, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Ismaninger Strasse 22, 81675, Munich, Germany.; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., van der Garde M; Department of Medicine III, School of Medicine, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany. mark.garde@tum.de.; German Cancer Consortium (DKTK), Partner Site Munich, Ismaninger Strasse 22, 81675, Munich, Germany. mark.garde@tum.de.; German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. mark.garde@tum.de. |
المصدر: | Stem cell research & therapy [Stem Cell Res Ther] 2023 Mar 08; Vol. 14 (1), pp. 36. Date of Electronic Publication: 2023 Mar 08. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central |
مواضيع طبية MeSH: | Hematologic Neoplasms* , Mesenchymal Stem Cells*, Humans ; Bone Marrow Cells ; Hematopoietic Stem Cells ; Femur Head |
مستخلص: | Bone marrow samples from discarded femoral heads are often used as healthy controls in studies investigating the in vitro characteristics of cells from patients with hematologic malignancies. Since patient samples are usually derived from iliac crest aspirates, this carries the risk that the properties of the cells from both sources might be different due to the site and method of harvesting. Comparing BM cells from iliac crest aspirates and femoral heads from age-matched healthy donors, we show that, while mesenchymal stromal cells have indistinguishable properties between both sources, hematopoietic stem and progenitor cells (HSPC) from femoral heads show a considerable proliferative advantage in vitro. These data therefore suggest that experiments comparing leukemic cells from the iliac crest to healthy HSPC obtained from femoral heads should be interpreted with caution. (© 2023. The Author(s).) |
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فهرسة مساهمة: | Keywords: Femoral head; Healthy control; Hematopoietic stem cells; Iliac crest; Mesenchymal stromal cells |
تواريخ الأحداث: | Date Created: 20230307 Date Completed: 20230309 Latest Revision: 20230327 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9993599 |
DOI: | 10.1186/s13287-023-03257-z |
PMID: | 36882822 |
قاعدة البيانات: | MEDLINE |
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