دورية أكاديمية
Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease.
| العنوان: | Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease. |
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| المؤلفون: | Zeng S; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA., Rosati E; Institute of Immunology & Institute of Clinical Molecular Biology, Christian-Albrechts Universität zu Kiel and Universitätsklinik Schleswig-Holstein, Kiel, Germany., Saggau C; Institute of Immunology & Institute of Clinical Molecular Biology, Christian-Albrechts Universität zu Kiel and Universitätsklinik Schleswig-Holstein, Kiel, Germany., Messner B; Institute of Immunology & Institute of Clinical Molecular Biology, Christian-Albrechts Universität zu Kiel and Universitätsklinik Schleswig-Holstein, Kiel, Germany., Chu H; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Duan Y; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Hartmann P; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Division of Gastroenterology, Hepatology & Nutrition, Rady Children's Hospital San Diego, San Diego, CA, USA., Wang Y; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA., Ma S; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Huang WJM; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Lee J; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Lee SM; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Carvalho-Gontijo R; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Zhang V; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Hoffmann JP; Center for Translational Research in Infection and Inflammation, Department of Pediatrics and Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Kolls JK; Center for Translational Research in Infection and Inflammation, Department of Pediatrics and Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Raz E; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Brenner DA; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Kisseleva T; Department of Surgery, University of California, San Diego, La Jolla, CA, USA., LeibundGut-Landmann S; Section of Immunology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland; Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland., Bacher P; Institute of Immunology & Institute of Clinical Molecular Biology, Christian-Albrechts Universität zu Kiel and Universitätsklinik Schleswig-Holstein, Kiel, Germany., Stärkel P; St. Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium., Schnabl B; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, CA, USA. Electronic address: beschnabl@health.ucsd.edu. |
| المصدر: | Cell host & microbe [Cell Host Microbe] 2023 Mar 08; Vol. 31 (3), pp. 389-404.e7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press |
| مواضيع طبية MeSH: | Candida albicans* , Th17 Cells*, Mice ; Animals ; Candida ; Mice, Transgenic ; Ethanol/toxicity |
| مستخلص: | Alcohol-associated liver disease is accompanied by intestinal mycobiome dysbiosis, yet the impacts on liver disease are unclear. We demonstrate that Candida albicans-specific T helper 17 (Th17) cells are increased in circulation and present in the liver of patients with alcohol-associated liver disease. Chronic ethanol administration in mice causes migration of Candida albicans (C. albicans)-reactive Th17 cells from the intestine to the liver. The antifungal agent nystatin decreased C. albicans-specific Th17 cells in the liver and reduced ethanol-induced liver disease in mice. Transgenic mice expressing T cell receptors (TCRs) reactive to Candida antigens developed more severe ethanol-induced liver disease than transgene-negative littermates. Adoptively transferring Candida-specific TCR transgenic T cells or polyclonal C. albicans-primed T cells exacerbated ethanol-induced liver disease in wild-type mice. Interleukin-17 (IL-17) receptor A signaling in Kupffer cells was required for the effects of polyclonal C. albicans-primed T cells. Our findings indicate that ethanol increases C. albicans-specific Th17 cells, which contribute to alcohol-associated liver disease. Competing Interests: Declaration of interests B.S. has been consulting for Ambys Medicines, Ferring Research Institute, Gelesis, HOST Therabiomics, Intercept Pharmaceuticals, Mabwell Therapeutics, Patara Pharmaceuticals, and Takeda. B.S.’s institution UC San Diego has received research support from Artizan Biosciences, Axial Biotherapeutics, BiomX, CymaBay Therapeutics, NGM Biopharmaceuticals, Prodigy Biotech, and Synlogic Operating Company. B.S. is the founder of Nterica Bio. UC San Diego has filed several patents with B.S. and Y.D. as inventors related to this work. P.S. received grant support from Gilead Sciences Belgium. (Published by Elsevier Inc.) |
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| معلومات مُعتمدة: | R35 HL139930 United States HL NHLBI NIH HHS; R01 HL141999 United States HL NHLBI NIH HHS; I01 BX004594 United States BX BLRD VA; P42 ES010337 United States ES NIEHS NIH HHS; P30 DK120515 United States DK NIDDK NIH HHS; R01 DK099205 United States DK NIDDK NIH HHS; R01 AA028550 United States AA NIAAA NIH HHS; R01 GM124494 United States GM NIGMS NIH HHS; P50 AA011999 United States AA NIAAA NIH HHS; U01 AA026939 United States AA NIAAA NIH HHS; U01 AA029019 United States AA NIAAA NIH HHS; R01 AA024726 United States AA NIAAA NIH HHS; R01 DK091183 United States DK NIDDK NIH HHS; R37 AA020703 United States AA NIAAA NIH HHS; KL2 TR001444 United States TR NCATS NIH HHS; R01 DK101737 United States DK NIDDK NIH HHS; R44 DK115242 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: ALD; alcoholic liver disease; microbiome; microbiota; mycobiome |
| المشرفين على المادة: | 3K9958V90M (Ethanol) |
| تواريخ الأحداث: | Date Created: 20230309 Date Completed: 20230313 Latest Revision: 20240321 |
| رمز التحديث: | 20240321 |
| مُعرف محوري في PubMed: | PMC10039706 |
| DOI: | 10.1016/j.chom.2023.02.001 |
| PMID: | 36893735 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1934-6069 |
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| DOI: | 10.1016/j.chom.2023.02.001 |