دورية أكاديمية
Haploidentical hematopoietic stem cell transplantation as individual treatment option in pediatric patients with very high-risk sarcomas.
| العنوان: | Haploidentical hematopoietic stem cell transplantation as individual treatment option in pediatric patients with very high-risk sarcomas. |
|---|---|
| المؤلفون: | Eichholz T; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Döring M; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Giardino S; Hematopoietic Stem Cell Transplantation Unit, Department of Hematology and Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Gruhn B; Department of Pediatrics, Jena University Hospital, Jena, Germany., Seitz C; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Flaadt T; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Schwinger W; Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Ebinger M; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Holzer U; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Mezger M; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Teltschik HM; Klinikum der Landeshauptstadt Stuttgart gKAöR, Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pädiatrie 5 (Pädiatrische Onkologie, Hämatologie, Immunologie), Stuttgart, Germany., Sparber-Sauer M; Klinikum der Landeshauptstadt Stuttgart gKAöR, Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pädiatrie 5 (Pädiatrische Onkologie, Hämatologie, Immunologie), Stuttgart, Germany.; University Tübingen, Medical Faculty, Tübingen, Germany., Koscielniak E; Klinikum der Landeshauptstadt Stuttgart gKAöR, Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pädiatrie 5 (Pädiatrische Onkologie, Hämatologie, Immunologie), Stuttgart, Germany.; University Tübingen, Medical Faculty, Tübingen, Germany., Abele M; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Handgretinger R; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany., Lang P; University Children's Hospital, Eberhard Karls University, Tuebingen, Germany. |
| المصدر: | Frontiers in oncology [Front Oncol] 2023 Feb 21; Vol. 13, pp. 1064190. Date of Electronic Publication: 2023 Feb 21 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مستخلص: | Background: Prognosis of children with primary disseminated or metastatic relapsed sarcomas remains dismal despite intensification of conventional therapies including high-dose chemotherapy. Since haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is effective in the treatment of hematological malignancies by mediating a graft versus leukemia effect, we evaluated this approach in pediatric sarcomas as well. Methods: Patients with bone Ewing sarcoma or soft tissue sarcoma who received haplo-HSCT as part of clinical trials using CD3+ or TCRα/β+ and CD19+ depletion respectively were evaluated regarding feasibility of treatment and survival. Results: We identified 15 patients with primary disseminated disease and 14 with metastatic relapse who were transplanted from a haploidentical donor to improve prognosis. Three-year event-free survival (EFS) was 18,1% and predominantly determined by disease relapse. Survival depended on response to pre-transplant therapy (3y-EFS of patients in complete or very good partial response: 36,4%). However, no patient with metastatic relapse could be rescued. Conclusion: Haplo-HSCT for consolidation after conventional therapy seems to be of interest for some, but not for the majority of patients with high-risk pediatric sarcomas. Evaluation of its future use as basis for subsequent humoral or cellular immunotherapies is necessary. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Eichholz, Döring, Giardino, Gruhn, Seitz, Flaadt, Schwinger, Ebinger, Holzer, Mezger, Teltschik, Sparber-Sauer, Koscielniak, Abele, Handgretinger and Lang.) |
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| فهرسة مساهمة: | Keywords: Ewing sarcoma; haploidentical hematopoietic stem cell transplantation; pediatric sarcoma; rhabdomyosarcoma; soft tissue sarcoma |
| تواريخ الأحداث: | Date Created: 20230310 Latest Revision: 20230311 |
| رمز التحديث: | 20230311 |
| مُعرف محوري في PubMed: | PMC9990259 |
| DOI: | 10.3389/fonc.2023.1064190 |
| PMID: | 36895486 |
| قاعدة البيانات: | MEDLINE |
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