دورية أكاديمية
Evaluation of altered environmental conditions as a decontamination approach for SARS-CoV-2 when applied to aircraft related materials.
| العنوان: | Evaluation of altered environmental conditions as a decontamination approach for SARS-CoV-2 when applied to aircraft related materials. |
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| المؤلفون: | Richter W; Battelle Memorial Institute, Health, Columbus, OH, USA., Sunderman M; Battelle Memorial Institute, Health, Columbus, OH, USA., Fulton M; Battelle Memorial Institute, Health, Columbus, OH, USA., Catyb J; Battelle Memorial Institute, Health, Columbus, OH, USA., Lewis D; Air Force Institute of Technolog, Biodefense Science, Wright-Patterson Air Force Basey, Dayton, OH, USA. |
| المصدر: | Journal of applied microbiology [J Appl Microbiol] 2023 May 02; Vol. 134 (5). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9706280 Publication Model: Print Cited Medium: Internet ISSN: 1365-2672 (Electronic) Linking ISSN: 13645072 NLM ISO Abbreviation: J Appl Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : Oxford : Oxford University Press Original Publication: Oxford : Published for the Society for Applied Bacteriology by Blackwell Science, c1997- |
| مواضيع طبية MeSH: | SARS-CoV-2* , COVID-19*, Humans ; Decontamination/methods ; Plastics ; Humidity |
| مستخلص: | Aims: The purpose of this study was to evaluate the effects of altered environmental conditions, specifically elevated temperature at various levels of expected relative humidity (RH), on the inactivation of SARS-CoV-2 when applied to U.S. Air Force aircraft materials. Methods and Results: SARS CoV-2 (USA-WA1/2020) was spiked (∼1 × 105 TCID50) in either synthetic saliva or lung fluid, dried onto porous (e.g. Nylon strap) and nonporous materials (e.g. bare aluminum, silicone, and ABS plastic), placed in a test chamber and exposed to environmental conditions ranging from 40 to 51.7 °C and RH ranging from 0% to 50%. The amount of infectious SARS-CoV-2 was then assessed at various timepoints from 0 to 2 days. Warmer test temperatures, higher RH, and longer exposure duration resulted in higher inactivation rates per material type. Synthetic saliva inoculation vehicle was more readily decontaminated compared to materials inoculated with synthetic lung fluid. Conclusions: SARS-CoV-2 was readily inactivated below limit of quantitation (LOQ) for all materials inoculated using synthetic saliva vehicle within 6 hours when exposed to environmental conditions of 51.7 °C and RH ≥ 25%. Synthetic lung fluid vehicle did not follow the general trend of an increase in RH resulting in increased efficacy. The lung fluid performed best at the 20%-25% RH range to achieve complete inactivation below LOQ. (© The Author(s) 2023. Published by Oxford University Press on behalf of Applied Microbiology International.) |
| معلومات مُعتمدة: | BAA AFRL-RQKHC-2016-0009/FA8650-19-2-6985 711th Human Performance Wing |
| فهرسة مساهمة: | Keywords: COVID-19; SARS-CoV-2; aircraft; decontamination; inactivation; materials; persistence |
| المشرفين على المادة: | 0 (Plastics) |
| تواريخ الأحداث: | Date Created: 20230310 Date Completed: 20230503 Latest Revision: 20230503 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1093/jambio/lxad051 |
| PMID: | 36898667 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1365-2672 |
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| DOI: | 10.1093/jambio/lxad051 |