دورية أكاديمية

Immunotherapy in malignant peritoneal mesothelioma (Review).

التفاصيل البيبلوغرافية
العنوان: Immunotherapy in malignant peritoneal mesothelioma (Review).
المؤلفون: Alaklabi S; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Roy AM; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Skitzki JJ; Department of Surgical Oncology/Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Iyer R; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
المصدر: Molecular and clinical oncology [Mol Clin Oncol] 2023 Feb 22; Vol. 18 (4), pp. 31. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2023).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Spandidos Publications UK Ltd Country of Publication: England NLM ID: 101613422 Publication Model: eCollection Cited Medium: Internet ISSN: 2049-9469 (Electronic) Linking ISSN: 20499450 NLM ISO Abbreviation: Mol Clin Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London, UK : Spandidos Publications UK Ltd
مستخلص: Over the last decade, there has been a movement in cancer treatment away from cytotoxic therapies toward strategies that enhance the immune system against cancer. Immune checkpoint inhibitors (ICIs) have been incorporated into the treatment regimens for patients with various solid tumors. Mesothelioma trials revealed encouraging efficacy; however, patients with peritoneal mesothelioma are usually excluded, slowing the progress of improving the treatment of this aggressive cancer and compelling oncologist to rely on retrospective studies despite their flaws and limitations. Currently, there is no consensus on the role of ICIs in the treatment of malignant peritoneal mesothelioma (MPeM). The present review discusses data from clinical studies that examined immunotherapy in MPeM and evaluates what is known about the relevance of the tumor microenvironment and clinically validated biomarkers for ICIs efficacy. Furthermore, a proposed strategy for utilizing immunotherapy in treating MPeM is discussed.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2020, Spandidos Publications.)
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فهرسة مساهمة: Keywords: clinical trials; efficacy; immune checkpoint inhibitors; peritoneal mesothelioma; tumor microenvironment
تواريخ الأحداث: Date Created: 20230313 Latest Revision: 20230314
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC9995593
DOI: 10.3892/mco.2023.2627
PMID: 36908980
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9469
DOI:10.3892/mco.2023.2627