دورية أكاديمية
Multicomponent spectrophotometric determination of a ternary mixture of widely-prescribed cardiovascular drugs by four different methods.
| العنوان: | Multicomponent spectrophotometric determination of a ternary mixture of widely-prescribed cardiovascular drugs by four different methods. |
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| المؤلفون: | El-Awady MI; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Delta University for Science and Technology, International Coastal Road, Gamasa 11152, Egypt. Electronic address: mohamedelawady2@yahoo.com., El-Brashy AM; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Abdallah NA; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Ibrahim FA; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. |
| المصدر: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2023 Jul 05; Vol. 295, pp. 122573. Date of Electronic Publication: 2023 Mar 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9602533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3557 (Electronic) Linking ISSN: 13861425 NLM ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Kidlington, Oxford, U.K. ; Tarrytown, NY] : Pergamon, c1994- |
| مواضيع طبية MeSH: | Cardiovascular Agents*, Humans ; Ramipril ; Atorvastatin ; Spectrophotometry/methods ; Aspirin |
| مستخلص: | Four accurate, green, uncomplicated, and fast spectrophotometric procedures were established for the purpose of resolving as well as quantifying a ternary combination prescribed for cardiovascular patients, such as aspirin, atorvastatin, and ramipril. Method (A) is based on the first derivative zero-crossing spectrophotometry for the determination of aspirin and atorvastatin at 247.4 nm and 302.6 nm, respectively. Ramipril was determined using the second derivative at 211 nm. Method (B) depends on the ratio spectra first derivative (RDS) where the absorption spectrum of the ternary combination was divided by the spectrum of one of the analytes. When treated similarly, the concentrations of the other two analytes were measured using their corresponding calibration graphs. For the determination of ASP and RAM, ATR was used as a divisor with a concentration of 26 µg/mL, and the RDS values at 272.0 and 225.8 nm, respectively, were plotted against the ASP and RAM concentrations. Using 40 µg/mL ASP as a divisor, ATR was analyzed, and the RDS values at 295 nm were plotted versus the ATR concentration. Method (C) is based on the double divisor-ratio spectra derivative technique. In this technique, the derivative of the ratio spectrum is computed by dividing the absorption spectra of the studied combination by the standard spectrum of abinary combination of two of the three analytes being studied. The concentrations of the three analytes in the mixture were assayed by determining the absorbance either at the positive or the negative amplitude. For the determination of ASP, ATR, and RAM, the wavelengths used were 244, 295, and 220 nm, respectively. Method (D) was a hybrid double divisor-ratio spectra technique based on convolving the double divisor-ratio spectra with trigonometric Fourier functions. The magnitudes of the Fourier function coefficients at either maximum or minimum points were correlated to the concentration of each drug in the mixture. The specificity of the suggested methods was tested by analyzing synthetic laboratory-prepared combinations and laboratory-made tablets. Furthermore, the accuracy and precision were ensured by statistically comparing the obtained results with those obtained from comparison method using Bartlett's Test for Equality of Variances and ANOVA test. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aspirin; Atorvastatin; Derivative ratio; Double divisor-ratio Spectra Derivative; Hybrid double divisor-ratio spectra; Ramipril |
| المشرفين على المادة: | 0 (Cardiovascular Agents) L35JN3I7SJ (Ramipril) A0JWA85V8F (Atorvastatin) R16CO5Y76E (Aspirin) |
| تواريخ الأحداث: | Date Created: 20230315 Date Completed: 20230418 Latest Revision: 20230418 |
| رمز التحديث: | 20230418 |
| DOI: | 10.1016/j.saa.2023.122573 |
| PMID: | 36921519 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3557 |
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| DOI: | 10.1016/j.saa.2023.122573 |