دورية أكاديمية
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A randomized clinical trial of Premaquick biomarkers versus transvaginal cervical length for pre-induction cervical assessment at term among pregnant women.

التفاصيل البيبلوغرافية
العنوان: A randomized clinical trial of Premaquick biomarkers versus transvaginal cervical length for pre-induction cervical assessment at term among pregnant women.
المؤلفون: Okafor CG; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Eleje GU; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria.; Effective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Nnewi Campus, Awka, Nigeria., Adinma JI; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Ikechebelu JI; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria.; Effective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Nnewi Campus, Awka, Nigeria., Umeh EO; Department of Radiology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Okafor CO; Department of Radiology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Ugwu EO; Department of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Teaching Hospital, Enugu Campus, Enugu State, Nigeria., Ugboaja JO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Nwosu BO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Ezeama CO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Udigwe GO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria.; Effective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Nnewi Campus, Awka, Nigeria., Okoro CC; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Egeonu RO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Ezema EC; Essen Medical, Bronx, NY, USA., Umeononihu OS; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Okpala BC; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Okafor CC; Paediatric Surgery unit, Great Ormond Street Hospital, London, UK., Ofojebe CJ; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Ilika CP; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Oguejiofor CB; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Ogabido CA; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Umeokafor CC; Department of Radiology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., James JE; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Obiagwu HI; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Okafor LU; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Obidike AB; Department of Anaesthesia, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Okam PC; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Okeke KN; Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Inya AO; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Njoku TK; Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nnewi, Anambra State, Nigeria., Eleje LI; Evaluation, Research and Statistics Unit, Department of Educational Foundations, Faculty of Education, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
المصدر: SAGE open medicine [SAGE Open Med] 2023 Mar 11; Vol. 11, pp. 20503121231158220. Date of Electronic Publication: 2023 Mar 11 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 101624744 Publication Model: eCollection Cited Medium: Print ISSN: 2050-3121 (Print) Linking ISSN: 20503121 NLM ISO Abbreviation: SAGE Open Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : SAGE Publications
مستخلص: Objectives: To compare Premaquick biomarkers (combined insulin-like growth-factor binding protein 1 and interleukin-6) and cervical length measurement via transvaginal ultrasound for pre-induction cervical evaluation at term among pregnant women.
Methods: A randomized clinical trial of consenting pregnant women at the Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria. The women were randomized equally into Premaquick group ( n  = 36) and transvaginal ultrasound group ( n  = 36). The cervix was adjudged 'ripe' if the Premaquick test was positive or if the trans-vaginal measured cervical length was less than 28 mm. The primary outcome measures were the proportions of women who needed prostaglandin analogue for cervical ripening and the proportion that achieved vaginal delivery after induction of labour. The trial was registered in Pan African clinical trial registry (PACTR) registry with approval number PACTR202001579275333.
Results: The baseline characteristics were similar between the two groups ( p  > 0.05). There was no statistically significant difference between the two groups in terms of proportion of women that required prostaglandins for pre-induction cervical ripening (41.7 versus 47.2%, p  = 0.427), vaginal delivery (77.8 versus 80.6%, p  = 0.783), mean induction to delivery interval (22.9 ± 2.81 h versus 24.04 ± 3.20 h, p  = 0.211), caesarean delivery (22.2 versus 19.4%, p  = 0.783), proportion of neonate with birth asphyxia (8.30 versus 8.30%, p  = 1.00) and proportion of neonate admitted into special care baby unit (16.7 versus 13.9%, p  = 0.872). Subgroup analysis of participants with 'ripe' cervix at initial pre-induction assessment showed that the mean induction to active phase of labour interval and mean induction to delivery interval were significantly shorter in Premaquick than transvaginal ultrasound group.
Conclusion: Pre-induction cervical assessment at term with either Premaquick biomarkers or transvaginal ultrasound for cervical length is effective, objective and safe with similar and comparable outcome. However, when compared with women with positive transvaginal ultrasound at initial assessment, women with positive Premaquick test at initial assessment showed a significantly shorter duration of onset of active phase of labour and delivery of baby following induction of labour.
Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2023.)
References: J Obstet Gynaecol India. 2018 Feb;68(1):51-57. (PMID: 29391676)
Am J Obstet Gynecol. 2011 Mar;204(3):223.e1-5. (PMID: 21376162)
J Perinat Med. 2017 Nov 27;45(8):915-924. (PMID: 28236632)
Obstet Gynecol. 1982 Aug;60(2):137-47. (PMID: 7155472)
Arch Gynecol Obstet. 2015 Jul;292(1):45-52. (PMID: 25524535)
Ultrasound Obstet Gynecol. 2005 Feb;25(2):155-9. (PMID: 15660437)
Acta Obstet Gynecol Scand. 2001 Jun;80(6):546-51. (PMID: 11380291)
J Matern Fetal Neonatal Med. 2010 Dec;23(12):1406-12. (PMID: 20230317)
J Obstet Gynaecol Res. 2018 Aug;44(8):1404-1414. (PMID: 29956434)
J Obstet Gynaecol. 2012 Feb;32(2):145-7. (PMID: 22296424)
Obstet Gynecol. 1964 Aug;24:266-8. (PMID: 14199536)
Int J Gynaecol Obstet. 2020 May;149(2):171-177. (PMID: 32090329)
Ultrasound Obstet Gynecol. 2011 Aug;38(2):198-204. (PMID: 21484904)
Bosn J Basic Med Sci. 2015 Jan 08;15(1):51-6. (PMID: 25725144)
Acta Obstet Gynecol Scand. 2011 Jan;90(1):57-62. (PMID: 21275916)
N Engl J Med. 2018 Aug 09;379(6):513-523. (PMID: 30089070)
Am J Obstet Gynecol. 2016 Jan;214(1):57-73. (PMID: 26149828)
Cochrane Database Syst Rev. 2015 Jun 12;(6):CD010762. (PMID: 26068943)
J Obstet Gynaecol Res. 2009 Apr;35(2):301-6. (PMID: 19708177)
BJOG. 2017 Jul;124(8):1274-1283. (PMID: 27348806)
Obstet Gynecol. 1994 Feb;83(2):229-33. (PMID: 8290185)
J Obstet Gynaecol Res. 2015 Mar;41(3):377-82. (PMID: 25303725)
Biochem J. 2003 Aug 15;374(Pt 1):1-20. (PMID: 12773095)
J Matern Fetal Neonatal Med. 2022 Nov;35(22):4291-4298. (PMID: 33207972)
Arch Gynecol Obstet. 2012 Jun;285(6):1523-8. (PMID: 22198844)
فهرسة مساهمة: Keywords: Cervical length; Premaquick; interleukin-6; phosphorylated insulin-like growth factor-binding protein-1; pre-induction cervical assessment; term; transvaginal; ultrasound
تواريخ الأحداث: Date Created: 20230316 Latest Revision: 20230316
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10009056
DOI: 10.1177/20503121231158220
PMID: 36923111
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-3121
DOI:10.1177/20503121231158220