دورية أكاديمية
Prenylated dihydroflavones from the root barks of Morus alba .
| العنوان: | Prenylated dihydroflavones from the root barks of Morus alba . |
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| المؤلفون: | Zhu JY; School of Pharmaceutical Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, China., Weng HZ; School of Pharmaceutical Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, China., Tang DK; School of Pharmacy, Shenyang Pharmaceutical University, Shengyang, China., Long JC; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Tang ZY; School of Pharmaceutical Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, China., Chen Y; School of Pharmaceutical Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, China., Yin S; School of Pharmaceutical Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, China., Tang GH; School of Pharmaceutical Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou, China. |
| المصدر: | Natural product research [Nat Prod Res] 2024 Aug; Vol. 38 (15), pp. 2569-2576. Date of Electronic Publication: 2023 Mar 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Morus*/chemistry , Plant Bark*/chemistry , Plant Roots*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/isolation & purification , Prenylation*, Rats ; Animals ; PC12 Cells ; Molecular Structure ; Flavones/chemistry ; Flavones/isolation & purification ; Flavones/pharmacology ; Magnetic Resonance Spectroscopy |
| مستخلص: | Three new prenylated dihydroflavones, moralbaflavones A-C ( 1 - 3 ), together with four known ones ( 4a/4b , 5 , and 6 ) were isolated from the root barks of Morus alba L. Their structures including the absolute configurations were determined by the analysis of HRMS, NMR, and ECD data. The neuroprotective properties of these prenylated dihydroflavones were screened at the concentration of 10 µ M in the sodium nitroprusside-induced rat pheochromocytoma PC-12 cells, and the results showed moralbaflavone C ( 3 ) possessed significant neuroprotective activity, being more potent than the positive control edaravone. |
| فهرسة مساهمة: | Keywords: Moraceae; Morus alba; Neuroprotective activity; dihydroflavones; prenylated dihydroflavones |
| المشرفين على المادة: | 0 (Neuroprotective Agents) 0 (Flavones) |
| SCR Organism: | Morus alba |
| تواريخ الأحداث: | Date Created: 20230317 Date Completed: 20240715 Latest Revision: 20240715 |
| رمز التحديث: | 20240716 |
| DOI: | 10.1080/14786419.2023.2189710 |
| PMID: | 36927252 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2023.2189710 |