دورية أكاديمية
Coordination of hydralazine with Cu 2+ at acidic pH promotes its oxidative degradation at neutral pH.
| العنوان: | Coordination of hydralazine with Cu 2+ at acidic pH promotes its oxidative degradation at neutral pH. |
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| المؤلفون: | Korać Jačić J; Life Sciences Department, University of Belgrade - Institute for Multidisciplinary Research, Kneza Višeslava 1, 11000 Belgrade, Serbia. Electronic address: jskorac@gmail.com., Bajuk-Bogdanović D; Faculty of Physical Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia., Savić S; Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia., Božić Cvijan B; Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, P.O. Box 38, 11000 Belgrade, Serbia., Spasojević I; Life Sciences Department, University of Belgrade - Institute for Multidisciplinary Research, Kneza Višeslava 1, 11000 Belgrade, Serbia., Milenković MR; Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia. Electronic address: mrm@chem.bg.ac.rs. |
| المصدر: | Journal of inorganic biochemistry [J Inorg Biochem] 2023 Jun; Vol. 243, pp. 112181. Date of Electronic Publication: 2023 Mar 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, Elsevier. |
| مواضيع طبية MeSH: | Copper*/chemistry , Hydralazine*, Oxidation-Reduction ; Hydrogen-Ion Concentration ; Oxidative Stress |
| مستخلص: | Hydralazine (HL), a frequently prescribed oral antihypertensive drug, shows redox interactions with transition metals such as copper that are not fully understood. Copper may be present at high concentrations in the digestive tract and can affect oral drugs. An important parameter for such interactions is pH, which changes from acidic in the gastric juice to neutral pH in intestines. In this study, we examined interactions of HL with Cu 2+ ions in conditions that mimic pH shift in the digestive tract using UV-Vis, Raman and EPR spectroscopy, cyclic voltammetry and oximetry. In the acidic solution, Cu 2+ formed a stable mononuclear complex with two bidentate coordinated HL molecules. On the other hand, at neutral pH, Cu 2+ initiated oxidation and degradation of HL. The degradation was more rapid in the HL-Cu 2+ system that was initially prepared at acidic pH and then shifted to neutral pH. The formation of the complex at acidic pH increases the availability of Cu 2+ for redox reactions after the shift to neutral pH at which Cu 2+ is poorly soluble. These results imply that the change of pH along the digestive tract may promote HL degradation by allowing the formation of the complex at gastric pH which makes Cu 2+ available for subsequent oxidation of HL at neutral pH. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Complex; Copper; Hydralazine; Oxidative degradation |
| المشرفين على المادة: | 789U1901C5 (Copper) 26NAK24LS8 (Hydralazine) |
| تواريخ الأحداث: | Date Created: 20230317 Date Completed: 20230411 Latest Revision: 20230623 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jinorgbio.2023.112181 |
| PMID: | 36931150 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3344 |
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| DOI: | 10.1016/j.jinorgbio.2023.112181 |