دورية أكاديمية
أعرض في EDS

Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study.

التفاصيل البيبلوغرافية
العنوان: Imaging features of primary hepatic sarcomatoid carcinoma: Differentiation from hepatocellular carcinoma and intrahepatic cholangiocarcinoma on CT: A preliminary study.
المؤلفون: Chen L; Department of Radiology, Yiwu Central Hospital, Yiwu, Zhejiang, China.; Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Ruan S; College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou, Zhejiang, China., Wang P; Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Cheng Y; Department of Radiology, Yiwu Central Hospital, Yiwu, Zhejiang, China., Wang Y; Department of Radiology, Yiwu Central Hospital, Yiwu, Zhejiang, China.; Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Tian W; College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou, Zhejiang, China., Zhang H; Department of Radiology, Yiwu Central Hospital, Yiwu, Zhejiang, China., Zhang X; Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Liang W; Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
المصدر: Heliyon [Heliyon] 2023 Mar 02; Vol. 9 (3), pp. e14123. Date of Electronic Publication: 2023 Mar 02 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Purpose: Primary hepatic sarcomatoid carcinoma (PHSC) is a rare type of malignant tumor in the liver. Nevertheless, few studies have focused on the imaging diagnosis of PHSC. In this study, we collected clinical and computed tomography (CT) imaging data of PHSC from two institutions, aiming to investigate the clinical and radiological characteristics of PHSC.
Methods: We retrospectively investigated the clinical characteristics and CT features of 22 PHSC patients (19 males and 3 females; mean age, 63.4 years; range, 49 to 76 years), 95 hepatocellular carcinoma (HCC) patients and 50 intrahepatic cholangiocarcinoma (ICC) patients. Two radiologists independently evaluated the CT features of the three groups. Subsequently, we analyzed the differences in the clinical characteristics and CT features between the PHSC and control groups.
Results: Most PHSCs were larger than 5 cm (72.7%). PHSC mainly showed irregular (81.8%), heterogeneous (100%) masses with ill-defined (72.7%) borders with necrosis (86.4%) on CT, which are more common CT features versus HCC ( p  < 0.001). In the arterial phase, PHSC always showed noticeable heterogeneous enhancement (100.0%), mainly manifesting as partial arterial phase hyperenhancement (APHE) (86.4%). The enhancement patterns of PHSC mainly included delayed progressive enhancement (72.7%), nonperipheral washout (22.7%), and unclassified enhancement (4.5%), which were significantly different from the HCC enhancement pattern but similar to the enhancement pattern of ICC. In addition, vein tumor thrombus (18.2%), intrahepatic metastasis (27.3%), and lymphadenopathy (27.3%) were relatively common in PHSC. Furthermore, most PHSC tumors classified as LR-M (66.7%) were similar to ICC.
Conclusions: PHSC generally presents as irregularly large masses with necrosis, intrahepatic metastasis, and lymphadenopathy. The CT enhancement of PHSC is mainly part of APHE and delayed progressive enhancement.
Competing Interests: The authors declare no competing interests.
(© 2023 The Authors.)
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فهرسة مساهمة: Keywords: AFP, alpha-fetoprotein; APHE, arterial phase hyperenhancement; CA125, carbohydrate antigen 12-5; CA199, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen; CKpan, pan-cytokeratin; CT, computed tomography; Computed tomography; GPC3, glypican-3; H&E, hematoxylin-eosin; HCC, hepatocellular carcinoma; Hepatic sarcomatoid carcinoma; Hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma; Imaging; Intrahepatic cholangiocarcinoma; MRI, magnetic resonance imaging; PHSC, primary hepatic sarcomatoid carcinoma; TACE, transcatheter arterial chemoembolization
تواريخ الأحداث: Date Created: 20230320 Latest Revision: 20230321
رمز التحديث: 20230321
مُعرف محوري في PubMed: PMC10018468
DOI: 10.1016/j.heliyon.2023.e14123
PMID: 36938423
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2023.e14123