دورية أكاديمية
3D-printed iodine-ink CT phantom for radiomics feature extraction - advantages and challenges.
| العنوان: | 3D-printed iodine-ink CT phantom for radiomics feature extraction - advantages and challenges. |
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| المؤلفون: | Bach M; Clinic of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Aberle C; Clinic of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Depeursinge A; University of Applied Sciences Western Switzerland (HES-SO) Valais, Sierre, Switzerland.; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland., Jimenez-Del-Toro O; University of Applied Sciences Western Switzerland (HES-SO) Valais, Sierre, Switzerland., Schaer R; University of Applied Sciences Western Switzerland (HES-SO) Valais, Sierre, Switzerland., Flouris K; Computer Vision Lab, ETH Zurich, Zurich, Switzerland., Konukoglu E; Computer Vision Lab, ETH Zurich, Zurich, Switzerland., Müller H; University of Applied Sciences Western Switzerland (HES-SO) Valais, Sierre, Switzerland.; Faculty of Medicine, University of Geneva (UNIGE), Geneva, Switzerland., Stieltjes B; Clinic of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Obmann MM; Clinic of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland. |
| المصدر: | Medical physics [Med Phys] 2023 Sep; Vol. 50 (9), pp. 5682-5697. Date of Electronic Publication: 2023 Apr 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 0425746 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2473-4209 (Electronic) Linking ISSN: 00942405 NLM ISO Abbreviation: Med Phys Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : Hoboken, NJ : John Wiley and Sons, Inc. Original Publication: Lancaster, Pa., Published for the American Assn. of Physicists in Medicine by the American Institute of Physics. |
| مواضيع طبية MeSH: | Ink* , Tomography, X-Ray Computed*/methods, Humans ; Phantoms, Imaging ; Printing, Three-Dimensional |
| مستخلص: | Background: To test and validate novel CT techniques, such as texture analysis in radiomics, repeat measurements are required. Current anthropomorphic phantoms lack fine texture and true anatomic representation. 3D-printing of iodinated ink on paper is a promising phantom manufacturing technique. Previously acquired or artificially created CT data can be used to generate realistic phantoms. Purpose: To present the design process of an anthropomorphic 3D-printed iodine ink phantom, highlighting the different advantages and pitfalls in its use. To analyze the phantom's X-ray attenuation properties, and the influences of the printing process on the imaging characteristics, by comparing it to the original input dataset. Methods: Two patient CT scans and artificially generated test patterns were combined in a single dataset for phantom printing and cropped to a size of 26 × 19 × 30 cm 3 . This DICOM dataset was printed on paper using iodinated ink. The phantom was CT-scanned and compared to the original image dataset used for printing the phantom. The water-equivalent diameter of the phantom was compared to that of a patient cohort (N = 104). Iodine concentrations in the phantom were measured using dual-energy CT. 86 radiomics features were extracted from 10 repeat phantom scans and the input dataset. Features were compared using a histogram analysis and a PCA individually and overall, respectively. The frequency content was compared using the normalized spectrum modulus. Results: Low density structures are depicted incorrectly, while soft tissue structures show excellent visual accordance with the input dataset. Maximum deviations of around 30 HU between the original dataset and phantom HU values were observed. The phantom has X-ray attenuation properties comparable to a lightweight adult patient (∼54 kg, BMI 19 kg/m 2 ). Iodine concentrations in the phantom varied between 0 and 50 mg/ml. PCA of radiomics features shows different tissue types separate in similar areas of PCA representation in the phantom scans as in the input dataset. Individual feature analysis revealed systematic shift of first order radiomics features compared to the original dataset, while some higher order radiomics features did not. The normalized frequency modulus |f(ω)| of the phantom data agrees well with the original data. However, all frequencies systematically occur more frequently in the phantom compared to the maximum of the spectrum modulus than in the original data set, especially for mid-frequencies (e.g., for ω = 0.3942 mm -1 , |f(ω)| Conclusions: 3D-iodine-ink-printing technology can be used to print anthropomorphic phantoms with a water-equivalent diameter of a lightweight adult patient. Challenges include small residual air enclosures and the fidelity of HU values. For soft tissue, there is a good agreement between the HU values of the phantom and input data set. Radiomics texture features of the phantom scans are similar to the input data set, but systematic shifts of radiomics features in first order features, due to differences in HU values, need to be considered. The paper substrate influences the spatial frequency distribution of the phantom scans. This phantom type is of very limited use for dual-energy CT analyses. (© 2023 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.) |
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| معلومات مُعتمدة: | QA4IQI The Swiss Personalized Health Network |
| فهرسة مساهمة: | Keywords: 15 quantitative imaging/analysis, 18 image reconstruction, 26 biomarkers, 3 IM-CT, 8 phantoms; physical |
| تواريخ الأحداث: | Date Created: 20230322 Date Completed: 20230911 Latest Revision: 20230911 |
| رمز التحديث: | 20230911 |
| DOI: | 10.1002/mp.16373 |
| PMID: | 36945890 |
| قاعدة البيانات: | MEDLINE |
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