دورية أكاديمية
أعرض في EDS

Body mass index is negatively associated with a good perinatal outcome after in vitro fertilization among patients with polycystic ovary syndrome: a national study.

التفاصيل البيبلوغرافية
العنوان: Body mass index is negatively associated with a good perinatal outcome after in vitro fertilization among patients with polycystic ovary syndrome: a national study.
المؤلفون: Hynes JS; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke Fertility Center, Durham, NC., Weber JM; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC., Truong T; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC., Acharya KS; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke Fertility Center, Durham, NC., Eaton JL; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke Fertility Center, Durham, NC.
المصدر: F&S reports [F S Rep] 2022 Dec 02; Vol. 4 (1), pp. 77-84. Date of Electronic Publication: 2022 Dec 02 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101766618 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3341 (Electronic) Linking ISSN: 26663341 NLM ISO Abbreviation: F S Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier Inc., [2020]-
مستخلص: Objective: To evaluate the association between body mass index (BMI) and good perinatal outcomes after in vitro fertilization (IVF) among women with polycystic ovary syndrome (PCOS).
Design: Retrospective cohort study using 2012-2015 Society for Assisted Reproductive Technology Clinic Outcomes Reporting System data.
Setting: Fertility clinics.
Patients: To identify patients most likely to have PCOS, we included women with a diagnosis of ovulation disorder and serum antimüllerian hormone >4.45 ng/mL. Exclusion criteria included age ≥ 41 years, secondary diagnosis of diminished ovarian reserve, preimplantation genetic testing, and missing BMI or primary outcome data.
Interventions: None.
Main Outcome Measures: Good perinatal outcome, defined as a singleton live birth at ≥ 37 weeks with birth weight ≥ 2,500 g and ≤ 4,000 g.
Results: The analysis included 9,521 fresh, autologous IVF cycles from 8,351 women. Among women with PCOS, the proportion of cycles with a good perinatal outcome was inversely associated with BMI: underweight 25.1%, normal weight 22.7%, overweight 18.9%, class I 18.4%, class II 14.9%, and class III or super obesity 12.2%. After adjusting for confounders, women in the highest BMI category had 51% reduced odds of a good perinatal outcome compared with normal weight women (adjusted odds ratio 0.49, 95% confidence interval 0.36-0.67).
Conclusions: Among women with PCOS undergoing fresh, autologous IVF, the odds of a good perinatal outcome decline with increasing BMI. Women with PCOS should be counseled that the odds of achieving a good perinatal outcome decrease as their weight increases.
(© 2022 The Authors.)
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فهرسة مساهمة: Keywords: IVF outcomes; PCOS; obesity; perinatal outcomes
تواريخ الأحداث: Date Created: 20230324 Latest Revision: 20230325
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10028420
DOI: 10.1016/j.xfre.2022.11.014
PMID: 36959962
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-3341
DOI:10.1016/j.xfre.2022.11.014