دورية أكاديمية
أعرض في EDS

DNA topoisomerase Top3β is impacted by early life stress in the developing female and male rat brain.

التفاصيل البيبلوغرافية
العنوان: DNA topoisomerase Top3β is impacted by early life stress in the developing female and male rat brain.
المؤلفون: Cuarenta A; Department of Psychology, University of Wisconsin-Madison, United States. Electronic address: cuarenta@wisc.edu., Kigar SL; Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, United States., Keese AP; Department of Psychology, University of Wisconsin-Madison, United States., Guagliardo SE; Department of Psychology, University of Wisconsin-Madison, United States., Chang L; Department of Psychology, University of Wisconsin-Madison, United States., Bakshi VP; Department of Psychiatry, University of Wisconsin-Madison, United States; Neuroscience Training Program, University of Wisconsin-Madison, United States., Auger AP; Department of Psychology, University of Wisconsin-Madison, United States; Neuroscience Training Program, University of Wisconsin-Madison, United States. Electronic address: apauger@wisc.edu.
المصدر: Brain research [Brain Res] 2023 Jun 15; Vol. 1809, pp. 148339. Date of Electronic Publication: 2023 Mar 24.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: DNA Topoisomerases, Type I*/chemistry , DNA Topoisomerases, Type I*/genetics , DNA Topoisomerases, Type I*/metabolism , Stress, Psychological*/metabolism, Animals ; Female ; Male ; Rats ; Brain/metabolism ; DNA ; DNA Topoisomerases/metabolism
مستخلص: DNA topoisomerases are essential for preserving genomic integrity. DNA topoisomerases induce breakage of DNA to facilitate replication and transcription by relaxing DNA and relieving supercoiling. Aberrant expression and deletions of topoisomerases are associated with psychiatric disorders such as schizophrenia and autism. Our study investigated the effects of early life stress (ELS) on three topoisomerases, Top1, Top3α, and Top3β in the developing rat brain. Newborn rats were exposed to a predator odor stress on postnatal days 1, 2, and 3; brain tissue was collected either 30 min after the last stressor on postnatal day 3 or during the juvenile period. We found that exposure to predator odor resulted in a decrease in Top3β expression levels in the neonatal male amygdala and in the juvenile prefrontal cortex of males and females. These data suggest that developing males and females respond differently to predator odor-induced stress. As ELS results in lower Top3β levels, these data suggest that ELS experienced during development may have consequences for genomic structural integrity and increased mental health risk.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Amygdala; Early life stress; Predator odor; Top3b; Topoisomerases
المشرفين على المادة: 9007-49-2 (DNA)
EC 5.99.1.- (DNA Topoisomerases)
EC 5.99.1.2 (DNA Topoisomerases, Type I)
EC 5.6.2.2 (Top3b protein, rat)
تواريخ الأحداث: Date Created: 20230326 Date Completed: 20230516 Latest Revision: 20230516
رمز التحديث: 20240829
DOI: 10.1016/j.brainres.2023.148339
PMID: 36966960
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6240
DOI:10.1016/j.brainres.2023.148339