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Phytochemical Screening, Antioxidant Activity, and Acute Toxicity Evaluation of Senna italica Extract Used in Traditional Medicine.

التفاصيل البيبلوغرافية
العنوان: Phytochemical Screening, Antioxidant Activity, and Acute Toxicity Evaluation of Senna italica Extract Used in Traditional Medicine.
المؤلفون: Towanou R; Non-Communicable Diseases and Cancer Research Unit, Laboratory of Applied Biology Research, Polytechnic School of Abomey-Calavi, Abomey-Calavi, Benin.; Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Godomey, Benin.; Laboratory of Biology and Molecular Typing in Microbiology, Faculty of Science and Technology, University of Abomey-Calavi, Cotonou, Benin., Konmy B; Laboratory of Biology and Molecular Typing in Microbiology, Faculty of Science and Technology, University of Abomey-Calavi, Cotonou, Benin.; Zootechnical Research and Livestock System Unit, Laboratory of Animal and Fisheries Science (LaSAH), National University of Agriculture, Ketou, Benin., Yovo M; Research and Training Laboratory in Applied Chemistry (LERCA), Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin., Dansou CC; Zootechnical Research and Livestock System Unit, Laboratory of Animal and Fisheries Science (LaSAH), National University of Agriculture, Ketou, Benin., Dougnon V; Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Godomey, Benin., Loko FS; Research and Training Laboratory in Applied Chemistry (LERCA), Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, Cotonou, Benin., Akpovi CD; Non-Communicable Diseases and Cancer Research Unit, Laboratory of Applied Biology Research, Polytechnic School of Abomey-Calavi, Abomey-Calavi, Benin., Baba-Moussa L; Laboratory of Biology and Molecular Typing in Microbiology, Faculty of Science and Technology, University of Abomey-Calavi, Cotonou, Benin.
المصدر: Journal of toxicology [J Toxicol] 2023 Mar 17; Vol. 2023, pp. 6405415. Date of Electronic Publication: 2023 Mar 17 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101519097 Publication Model: eCollection Cited Medium: Print ISSN: 1687-8191 (Print) Linking ISSN: 16878191 NLM ISO Abbreviation: J Toxicol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cairo, Egypt] : Hindawi Pub. Corp., 2008-
مستخلص: Medicinal plants such as Senna italica are increasingly used for their purgative virtues to treat stomach aches, fever, and jaundice. This study aims to screen the phytochemical compounds and to assess the antioxidant activity in vitro and the acute oral toxicity in vivo of Senna italica leaves. The plant was harvested, dried, pulverized, and preserved. Phytochemical screening was performed using different laboratory protocols. Ethanolic and aqueous extracts were, respectively, obtained by maceration and decoction technics. The assay for free radical scavenging was used to examine the antioxidant activity using DPPH. Acute oral toxicity was performed with aqueous and ethanolic extracts at 5000 mg/kg of body weight on female albinos Wistar rats, weighing 152.44 ± 3.68 g. Subjects were checked for any signs of mortality and macroscopy toxicity during the 14 days of the study. Biochemical and hematological parameters were measured to assess liver and kidney functions, and histological analysis of these organs was conducted. Phytochemical analysis highlighted the presence of total phenols, flavones, tannins, alkaloids, and quinone derivatives. Semiethanolic (78  μ g/mL), ethanolic (9.7  μ g/mL), and aqueous extract (9.2  μ g/mL) showed an interesting antioxidant activity. Biochemical and hematological parameters were normal and not significantly different ( p > 0.05). The plant extracts did not produce any toxic effect or mortality at the provided dose. Senna italica extracts induced an increase in the volume of liver and kidney tissues but no necrosis. Thus, lethal dose 50 of Senna italica leaf extract is probably higher than 5000 mg/kg.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Rodrigue Towanou et al.)
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تواريخ الأحداث: Date Created: 20230327 Latest Revision: 20231106
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10038741
DOI: 10.1155/2023/6405415
PMID: 36968147
قاعدة البيانات: MEDLINE
الوصف
تدمد:1687-8191
DOI:10.1155/2023/6405415