دورية أكاديمية
Cervical cancer immune infiltration microenvironment identification, construction of immune scores, assisting patient prognosis and immunotherapy.
العنوان: | Cervical cancer immune infiltration microenvironment identification, construction of immune scores, assisting patient prognosis and immunotherapy. |
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المؤلفون: | Yao S; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei, China.; Hubei Cancer Clinical Study Center, Wuhan, Hubei, China., Zhao L; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, Macau SAR, China.; Ministry of Education (MoE) Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, Macau SAR, China., Chen S; Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China., Wang H; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei, China.; Hubei Cancer Clinical Study Center, Wuhan, Hubei, China., Gao Y; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei, China.; Hubei Cancer Clinical Study Center, Wuhan, Hubei, China., Shao NY; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau, Macau SAR, China.; Ministry of Education (MoE) Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, Macau SAR, China., Dai M; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei, China.; Hubei Cancer Clinical Study Center, Wuhan, Hubei, China., Cai H; Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.; Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei, China.; Hubei Cancer Clinical Study Center, Wuhan, Hubei, China. |
المصدر: | Frontiers in immunology [Front Immunol] 2023 Mar 10; Vol. 14, pp. 1135657. Date of Electronic Publication: 2023 Mar 10 (Print Publication: 2023). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
مواضيع طبية MeSH: | Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/therapy, Humans ; Female ; Immunotherapy ; Prognosis ; Multigene Family ; Cell Proliferation ; Tumor Microenvironment/genetics |
مستخلص: | Background: The immune microenvironment is of great significance in cervical cancer. However, there is still a lack of systematic research on the immune infiltration environment of cervical cancer. Methods: We obtained cervical cancer transcriptome data and clinical information from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases, evaluated the immune microenvironment of cervical cancer, determined immune subsets, constructed an immune cell infiltration scoring system, screened key immune-related genes, and performed single-cell data analysis and cell function analysis of key genes. Results: We combined the TCGA and GEO data sets and obtained three different immune cell populations. We obtained two gene clusters, extracted 119 differential genes, and established an immune cell infiltration (ICI) scoring system. Finally, three key genes, IL1B, CST7, and ITGA5, were identified, and single-cell sequencing data were mined to distribute these key genes in different cell types. By up-regulating CST7 and down-regulating IL1B and ITGA5, cervical cancer cells' proliferation ability and invasion ability were successfully reduced. Conclusion: We conducted a comprehensive assessment of the state of the tumor immune microenvironment in cervical cancer, constructed the ICI scoring system, and identified the ICI scoring system as a potential indicator of susceptibility to immunotherapy for cervical cancer, identifying key genes suggesting that IL1B, CST7, and ITGA5 play an essential role in cervical cancer. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Yao, Zhao, Chen, Wang, Gao, Shao, Dai and Cai.) |
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فهرسة مساهمة: | Keywords: ICI score; TMB; cervical cancer; immune infiltration; immune microenvironment |
تواريخ الأحداث: | Date Created: 20230327 Date Completed: 20230328 Latest Revision: 20230328 |
رمز التحديث: | 20230329 |
مُعرف محوري في PubMed: | PMC10037308 |
DOI: | 10.3389/fimmu.2023.1135657 |
PMID: | 36969161 |
قاعدة البيانات: | MEDLINE |
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