دورية أكاديمية

A Metal-Polyphenol-Based Oxygen Economizer and Fenton Reaction Amplifier for Self-Enhanced Synergistic Photothermal/Chemodynamic/Chemotherapy.

التفاصيل البيبلوغرافية
العنوان: A Metal-Polyphenol-Based Oxygen Economizer and Fenton Reaction Amplifier for Self-Enhanced Synergistic Photothermal/Chemodynamic/Chemotherapy.
المؤلفون: Shi H; School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China., Wang R; School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China., Cao HC; School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China., Guo HY; School of Public Health, Anhui Medical University, Hefei, 230032, P. R. China., Pan P; School of Pharmacy, Anhui Medical University, Hefei, 230032, P. R. China., Xiong CF; School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China., Zhang LJ; School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China., Yang Q; School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China., Wei S; School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China., Liu T; School of Biomedical Engineering, Anhui Medical University, Hefei, 230032, P. R. China.
المصدر: Advanced healthcare materials [Adv Healthc Mater] 2023 Jul; Vol. 12 (18), pp. e2300054. Date of Electronic Publication: 2023 Apr 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : Wiley-VCH, 2012-
مواضيع طبية MeSH: Doxorubicin*/pharmacology , Nanoparticles* , Neoplasms*/therapy, Humans ; Cell Line, Tumor ; Hydrogen Peroxide ; Hypoxia ; Iron ; Metals ; Oxygen ; Photothermal Therapy ; Drug Synergism
مستخلص: To overcome the limitations of doxorubicin (DOX) chemotherapy, nanomedicines that integrate additional photothermal therapy (PTT) and chemodynamic therapy (CDT) strategies are highlighted as promising alternatives for the treatment of malignant tumors. However, time-consuming preparation processes, biosafety concerns, and the bottlenecks of individual therapeutic modalities often limit the practical applications of this strategy. To address these issues, this work designs an oxygen economizer that additionally serves as a Fenton reaction amplifier through the simple assembly of epigallocatechin gallate (EGCG), pluronic F-127 (PF127), iron (III) ions, and doxorubicin (DOX) for the enhancement of synergistic PTT/CDT/chemotherapy. The resulting nanoformulation, EFPD, can target mitochondria and inhibit cell respiration to reduce O 2 consumption, thus boosting DOX-mediated H 2 O 2 generation for enhanced CDT and simultaneously improving hypoxia-limited DOX chemotherapy efficacy. Moreover, the coordination between EGCG and Fe 3+ provides EFPD with excellent photothermal conversion efficiencies (η = 34.7%) for PTT and photothermal-accelerated drug release. Experimental results indicate that EFPD-mediated synergistic enhancement of PTT/CDT/chemotherapy can achieve excellent therapeutic outcomes, including enhanced ablation of solid tumors, reduced metastasis and cardiotoxicity, and extended life spans.
(© 2023 Wiley-VCH GmbH.)
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فهرسة مساهمة: Keywords: cellular respiration inhibition; hydrogen peroxide production; photothermal therapy; synergistic therapy; tumor hypoxia
المشرفين على المادة: 80168379AG (Doxorubicin)
BBX060AN9V (Hydrogen Peroxide)
E1UOL152H7 (Iron)
0 (Metals)
S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20230328 Date Completed: 20230726 Latest Revision: 20230909
رمز التحديث: 20230910
DOI: 10.1002/adhm.202300054
PMID: 36977362
قاعدة البيانات: MEDLINE
الوصف
تدمد:2192-2659
DOI:10.1002/adhm.202300054