دورية أكاديمية
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Constituents of the Stem Bark of Symphonia globulifera Linn. f. with Antileishmanial and Antibacterial Activities.

التفاصيل البيبلوغرافية
العنوان: Constituents of the Stem Bark of Symphonia globulifera Linn. f. with Antileishmanial and Antibacterial Activities.
المؤلفون: Nguengang RT; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon.; Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon., Tchegnitegni BT; Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon., Nono ECN; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon., Bellier Tabekoueng G; Department of Chemistry, Faculty of Science, University of Douala, Douala P.O. Box 24157, Cameroon., Fongang YSF; Department of Chemistry, Higher Teachers' Training College, The University of Maroua, Maroua P.O. Box 55, Cameroon., Bankeu JJK; Department of Chemistry, Faculty of Science, The University of Bamenda, Bambili P.O. Box 39, Cameroon., Chouna JR; Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon., Nkenfou CN; Department of Biology, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon., Fekam FB; Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, University of Yaoundé I, Yaoundé P.O. Box 812, Cameroon., Sewald N; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany., Lenta BN; Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Mar 08; Vol. 28 (6). Date of Electronic Publication: 2023 Mar 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Plant Bark*/chemistry , Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/analysis, Animals ; Chlorocebus aethiops ; Vero Cells ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/analysis ; Plant Extracts/pharmacology ; Plant Extracts/analysis
مستخلص: The chemical investigation of the n -hexane fraction from the methanol extract of the stem bark of Symphonia globulifera Linn f., which displayed good in vitro activity against Leishmania donovani NR-48822 promastigotes (IC 50 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U ( 1 ), V ( 2 )/W ( 3 ), and a new tocotrienol derivative named globuliferanol ( 4 ), along with 11 known compounds ( 5 - 15 ). Their structures were elucidated based on their NMR and MS data. Some isolated compounds were assessed for both their antileishmanial and cytotoxic activities against L. donovani and Vero cells, respectively. Guttiferone K ( 5 ) exhibited the best potency (IC 50 3.30 μg/mL), but with low selectivity to Vero cells. The n -hexane fraction and some compounds were also assessed in vitro for their antibacterial activity against seven bacterial strains. All the samples exhibited moderate to potent antibacterial activity (MICs ≤ 15.6 µg/mL) against at least one of the tested strains.
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معلومات مُعتمدة: 57316173 German Academic Exchange Service; 57561808 German Academic Exchange Service
فهرسة مساهمة: Keywords: Clusiaceae; Symphonia globulifera; antibacterial; antileishmanial; cytotoxicity; guttiferone; polyprenylated benzophenones; tocotrienol
المشرفين على المادة: 2DDG612ED8 (n-hexane)
0 (Antiprotozoal Agents)
0 (Anti-Bacterial Agents)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20230329 Date Completed: 20230330 Latest Revision: 20230331
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10053230
DOI: 10.3390/molecules28062473
PMID: 36985446
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28062473