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Neuroprotective and Antiherpetic Properties of Polyphenolic Compounds from Maackia amurensis Heartwood.

التفاصيل البيبلوغرافية
العنوان: Neuroprotective and Antiherpetic Properties of Polyphenolic Compounds from Maackia amurensis Heartwood.
المؤلفون: Tarbeeva DV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia., Berdyshev DV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia., Pislyagin EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia., Menchinskaya ES; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia., Kim NY; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia., Kalinovskiy AI; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia., Krylova NV; G.P. Somov Institute of Epidemiology and Microbiology, Rospotrebnadzor, 690087 Vladivostok, Russia., Iunikhina OV; G.P. Somov Institute of Epidemiology and Microbiology, Rospotrebnadzor, 690087 Vladivostok, Russia., Persiyanova EV; G.P. Somov Institute of Epidemiology and Microbiology, Rospotrebnadzor, 690087 Vladivostok, Russia., Shchelkanov MY; G.P. Somov Institute of Epidemiology and Microbiology, Rospotrebnadzor, 690087 Vladivostok, Russia., Grigorchuk VP; Federal Scientific Center of the East Asia Terrestrial Biodiversity (Institute of Biology and Soil Science), Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia., Aminin DL; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia., Fedoreyev SA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Mar 13; Vol. 28 (6). Date of Electronic Publication: 2023 Mar 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Maackia*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry, Quercetin
مستخلص: In this study, we isolated a new isoflavanostilbene maackiapicevestitol ( 1 ) as a mixture of two stable conformers 1a and 1b as well as five previously known dimeric and monomeric stilbens: piceatannol ( 2 ), maackin ( 3 ), scirpusin A ( 4 ), maackiasine ( 5 ), and maackolin ( 6 ) from M. amurensis heartwood, using column chromatography on polyamide, silicagel, and C-18. The structures of these compounds were elucidated by NMR, HR-MS, and CD techniques. Maksar ® obtained from M. amurensis heartwood and polyphenolics 1 - 6 possessed moderate anti-HSV-1 activity in cytopathic effect (CPE) inhibition and RT-PCR assays. A model of PQ-induced neurotoxicity was used to study the neuroprotective potential of polyphenolic compounds from M. amurensis . Maksar ® showed the highest neuroprotective activity and increased cell viability by 18% at a concentration of 10 μg/mL. Maackolin ( 6 ) also effectively increased the viability of PQ-treated Neuro-2a cells and the value of mitochondrial membrane potential at concentrations up to 10 μΜ. Maksar ® and compounds 1 - 6 possessed higher FRAP and DPPH-scavenging effects than quercetin. However, only compounds 1 and 4 at concentrations of 10 μM as well as Maksar ® (10 μg/mL) statistically significantly reduced the level of intracellular ROS in PQ-treated Neuro-2a cells.
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معلومات مُعتمدة: 22-75-00084 Russian Science Foundation
فهرسة مساهمة: Keywords: antiherpetic activity; antioxidant activity; neuroprotection; polyphenolic compounds; stilbenes
المشرفين على المادة: 0 (Plant Extracts)
9IKM0I5T1E (Quercetin)
تواريخ الأحداث: Date Created: 20230329 Date Completed: 20230330 Latest Revision: 20230331
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10056899
DOI: 10.3390/molecules28062593
PMID: 36985562
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28062593