Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations.
| العنوان: | Integrated Drivers of Basal and Acute Immunity in Diverse Human Populations. |
|---|---|
| المؤلفون: | Souquette A, Allen EK, Oshansky CM, Tang L, Wong SS, Jeevan T, Shi L, Pounds S, Elias G, Kuan G, Balmaseda A, Zapata R, Shaw-Saliba K, Damme PV, Tendeloo VV, Dib JC, Ogunjimi B, Webby R, Schultz-Cherry S, Pekosz A, Rothman R, Gordon A, Thomas PG |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 26. Date of Electronic Publication: 2023 Mar 26. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Prior studies have identified genetic, infectious, and biological associations with immune competence and disease severity; however, there have been few integrative analyses of these factors and study populations are often limited in demographic diversity. Utilizing samples from 1,705 individuals in 5 countries, we examined putative determinants of immunity, including: single nucleotide polymorphisms, ancestry informative markers, herpesvirus status, age, and sex. In healthy subjects, we found significant differences in cytokine levels, leukocyte phenotypes, and gene expression. Transcriptional responses also varied by cohort, and the most significant determinant was ancestry. In influenza infected subjects, we found two disease severity immunophenotypes, largely driven by age. Additionally, cytokine regression models show each determinant differentially contributes to acute immune variation, with unique and interactive, location-specific herpesvirus effects. These results provide novel insight into the scope of immune heterogeneity across diverse populations, the integrative effects of factors which drive it, and the consequences for illness outcomes. |
| تواريخ الأحداث: | Date Created: 20230330 Latest Revision: 20230330 |
| رمز التحديث: | 20230331 |
| مُعرف محوري في PubMed: | PMC10055315 |
| DOI: | 10.1101/2023.03.25.534227 |
| PMID: | 36993205 |
| قاعدة البيانات: | MEDLINE |
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