دورية أكاديمية
A DELPHI study priority setting the remaining challenges for the use of routinely collected data in trials: COMORANT-UK.
| العنوان: | A DELPHI study priority setting the remaining challenges for the use of routinely collected data in trials: COMORANT-UK. |
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| المؤلفون: | Williams ADN; Centre for Trials Research, Cardiff University, Cardiff, UK., Davies G; UCL Great Ormond Street Institute of Child Health, London, UK., Farrin AJ; Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK., Mafham M; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Robling M; Centre for Trials Research, Cardiff University, Cardiff, UK.; DECIPHer - Centre for Development, Evaluation, Complexity and Implementation in Public Health Improvement, Cardiff University, Cardiff, UK., Sydes MR; MRC Clinical Trials Unit at UCL, Institute of Clinical Trial and Methodology, University College London, London, UK.; BHF Data Science Centre, Health Data Research UK, London, UK., Lugg-Widger FV; Centre for Trials Research, Cardiff University, Cardiff, UK. LuggFV@cardiff.ac.uk. |
| المصدر: | Trials [Trials] 2023 Mar 30; Vol. 24 (1), pp. 243. Date of Electronic Publication: 2023 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, 2006- |
| مواضيع طبية MeSH: | Research Design* , Routinely Collected Health Data*, Humans ; Delphi Technique ; Health Priorities ; United Kingdom ; Clinical Trials as Topic |
| مستخلص: | Background: Researchers are increasingly seeking to use routinely collected data to support clinical trials. This approach has the potential to transform the way clinical trials are conducted in the future. The availability of routinely collected data for research, whether healthcare or administrative, has increased, and infrastructure funding has enabled much of this. However, challenges remain at all stages of a trial life cycle. This study, COMORANT-UK, aimed to systematically identify, with key stakeholders across the UK, the ongoing challenges related to trials that seek to use routinely collected data. Methods: This three-step Delphi method consisted of two rounds of anonymous web-based surveys and a virtual consensus meeting. Stakeholders included trialists, data infrastructures, funders of trials, regulators, data providers and the public. Stakeholders identified research questions or challenges that they considered were of particular importance and then selected their top 10 in the second survey. The ranked questions were taken forward to the consensus meeting for discussion with representatives invited from the stakeholder groups. Results: In the first survey, 66 respondents yielded over 260 questions or challenges. These were thematically grouped and merged into a list of 40 unique questions. Eighty-eight stakeholders then ranked their top ten from the 40 questions in the second survey. The most common 14 questions were brought to the virtual consensus meeting in which stakeholders agreed a top list of seven questions. We report these seven questions which are within the following domains: trial design, Patient and Public Involvement, trial set-up, trial open and trial data. These questions address both evidence gaps (requiring further methodological research) and implementation gaps (requiring training and/or service re-organisation). Conclusion: This prioritised list of seven questions should inform the direction of future research in this area and should direct efforts to ensure that the benefits in major infrastructure for routinely collected data are achieved and translated. Without this and future work to address these questions, the potential societal benefits of using routinely collected data to help answer important clinical questions will not be realised. (© 2023. The Author(s).) |
| References: | Int J Popul Data Sci. 2020 Jan 30;5(1):1123. (PMID: 32935049) Int J Popul Data Sci. 2018 Sep 21;3(3):432. (PMID: 34095522) BMJ Open. 2021 Apr 29;11(4):e049093. (PMID: 33926985) Trials. 2020 May 12;21(1):398. (PMID: 32398093) Trials. 2021 May 10;22(1):340. (PMID: 33971933) J Adv Nurs. 2000 Oct;32(4):1008-15. (PMID: 11095242) Trials. 2018 Mar 1;19(1):147. (PMID: 29490702) Trials. 2019 Oct 15;20(1):593. (PMID: 31615577) BMJ Open. 2021 Jun 16;11(6):e043906. (PMID: 34135032) |
| معلومات مُعتمدة: | MC_UU_00004/08 United Kingdom MRC_ Medical Research Council; MR/T041285/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Consensus; Priority setting; Routinely collected data; Trials methodology |
| تواريخ الأحداث: | Date Created: 20230330 Date Completed: 20230403 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| مُعرف محوري في PubMed: | PMC10064573 |
| DOI: | 10.1186/s13063-023-07251-x |
| PMID: | 36997954 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1745-6215 |
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| DOI: | 10.1186/s13063-023-07251-x |