دورية أكاديمية
أعرض في EDS

Eucalcemia during lipopolysaccharide challenge in postpartum dairy cows: II. Calcium dynamics.

التفاصيل البيبلوغرافية
العنوان: Eucalcemia during lipopolysaccharide challenge in postpartum dairy cows: II. Calcium dynamics.
المؤلفون: Chandler TL; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853. Electronic address: tlc236@cornell.edu., Westhoff TA; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853., LaPierre PA; Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853., Frizzarini W; Department of Animal and Dairy Sciences, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706., Hernandez LL; Department of Animal and Dairy Sciences, College of Agriculture and Life Sciences, University of Wisconsin, Madison 53706., Overton TR; Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853., Mann S; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.
المصدر: Journal of dairy science [J Dairy Sci] 2023 May; Vol. 106 (5), pp. 3601-3614. Date of Electronic Publication: 2023 Mar 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Dairy Science Association Country of Publication: United States NLM ID: 2985126R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3198 (Electronic) Linking ISSN: 00220302 NLM ISO Abbreviation: J Dairy Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: Champaign, IL : American Dairy Science Association
Original Publication: Lancaster, Pa. [etc.]
مواضيع طبية MeSH: Hypocalcemia*/veterinary , Cattle Diseases*/chemically induced, Female ; Cattle ; Animals ; Calcium ; Lipopolysaccharides/adverse effects ; Serotonin ; Postpartum Period ; Lactation/physiology ; Milk ; Calcium, Dietary ; Parathyroid Hormone ; Diet/veterinary ; Mammals
مستخلص: Hypocalcemia induced by immune activation is a conserved response among mammals. Early postpartum cows will experience decreased circulating Ca concentrations following acute immune activation; however, the cause for decreased Ca concentration is unknown. Our objectives were to (1) describe Ca dynamics following an intravenous (IV) LPS challenge in early postpartum cows, and (2) compare inflammatory-induced changes in Ca dynamics between IV Ca-treated cows and control cows. Cows (n = 14, 8 ± 1 d in milk) were enrolled in a matched-pair randomized controlled design to receive IV Ca (IVCa) in a eucalcemic clamp for 12 h, or 0.9% NaCl (CTRL) following an IV LPS infusion (0.040 or 0.045 µg of LPS/kg of body weight over 1 h). During the 24 h following LPS infusion, circulating concentrations of parathyroid hormone and serotonin were measured, serum and urine samples were collected to calculate urinary fractional excretion of Ca (FECa), and fecal samples were collected to calculate Ca apparent digestibility (ADCa) using amylase-treated and ash-corrected undigested neutral detergent fiber after 240 h (uNDFom 240 ) as an internal marker. Changes in Ca intake and milk Ca secretion were also quantified and compared with baseline values. Cows were fasted during challenge and dry matter intake was 20 ± 5% less than baseline values on the day of challenge and did not differ between groups. On the day of challenge, milk Ca concentration increased, but milk yield decreased such that total Ca secreted in milk did not change from baseline. Urine FECa was low overall, but an interaction of treatment and time was identified such that FECa increased in IVCa but decreased in CTRL. Concentrations of parathyroid hormone increased and serotonin decreased following challenge. Fecal dry matter decreased from baseline, but did not differ between 6, 12, and 24 h, and did not differ between groups. An interaction of treatment and time was identified for ADCa and apparent digestibility of dry matter such that digestibility was decreased in CTRL but not IVCa at 6 h. Acute immune activation induced hypocalcemia in CTRL, and although urinary Ca excretion was not a primary cause, it is unclear to what degree hypocalcemia was due to altered ADCa. Eucalcemia appeared to alter adaptations in Ca homeostasis during immune activation as FECa was increased in IVCa animals.
(The Authors. Published by Elsevier Inc. and Fass Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).)
فهرسة مساهمة: Keywords: calcium; digestibility; inflammation; transition cow
المشرفين على المادة: SY7Q814VUP (Calcium)
0 (Lipopolysaccharides)
333DO1RDJY (Serotonin)
0 (Calcium, Dietary)
0 (Parathyroid Hormone)
تواريخ الأحداث: Date Created: 20230331 Date Completed: 20230425 Latest Revision: 20230425
رمز التحديث: 20230425
DOI: 10.3168/jds.2022-22775
PMID: 37002137
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-3198
DOI:10.3168/jds.2022-22775