دورية أكاديمية
أعرض في EDS

Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study.

التفاصيل البيبلوغرافية
العنوان: Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study.
المؤلفون: Attwood LO; Department of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia lucy.attwood1@monash.edu., Bryant M; Department of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia., Lee SJ; Department of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia., Vujovic O; Department of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia., Higgs P; Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.; Department of Public Health, La Trobe University, Melbourne, Victoria, Australia., Doyle JS; Department of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia., Stewardson AJ; Department of Infectious Diseases, the Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.
مؤلفون مشاركون: EMU Study Group
المصدر: BMJ open [BMJ Open] 2023 Apr 03; Vol. 13 (4), pp. e070236. Date of Electronic Publication: 2023 Apr 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مواضيع طبية MeSH: Dromaiidae* , Substance Abuse, Intravenous*/complications , Substance Abuse, Intravenous*/epidemiology, Humans ; Animals ; Aftercare ; Prospective Studies ; Cohort Studies ; Patient Discharge ; Australia/epidemiology ; Anti-Bacterial Agents/therapeutic use ; Multicenter Studies as Topic
مستخلص: Introduction: People who inject drugs (PWID) are at risk of invasive infections such as bloodstream infections, endocarditis, osteomyelitis and septic arthritis. Such infections require prolonged antibiotic therapy, but there is limited evidence about the optimal care model to deliver to this population. The Epidemiology and Management of invasive infections among people who Use drugs (EMU) study aims to (1) describe the current burden, clinical spectrum, management and outcomes of invasive infections in PWID; (2) determine the impact of currently available models of care on completion of planned antimicrobials for PWID admitted to hospital with invasive infections and (3) determine postdischarge outcomes of PWID admitted with invasive infections at 30 and 90 days.
Methods and Analysis: EMU is a prospective multicentre cohort study of Australian public hospitals who provide care to PWIDs with invasive infections. All patients who have injected drugs in the previous six months and are admitted to a participating site for management of an invasive infection are eligible. EMU has two components: (1) EMU-Audit will collect information from medical records, including demographics, clinical presentation, management and outcomes; (2) EMU-Cohort will augment this with interviews at baseline, 30 and 90 days post-discharge, and data linkage examining readmission rates and mortality. The primary exposure is antimicrobial treatment modality, categorised as inpatient intravenous antimicrobials, outpatient antimicrobial therapy, early oral antibiotics or lipoglycopeptide. The primary outcome is confirmed completion of planned antimicrobials. We aim to recruit 146 participants over a 2-year period.
Ethics and Dissemination: EMU has been approved by the Alfred Hospital Human Research Ethics Committee (Project number 78815.) EMU-Audit will collect non-identifiable data with a waiver of consent. EMU-Cohort will collect identifiable data with informed consent. Findings will be presented at scientific conferences and disseminated by peer-review publications.
Trial Registration Number: ACTRN12622001173785; Pre-results.
Competing Interests: Competing interests: PH has received investigator-driven research funding from Gilead Sciences and AbbVie for work on hepatitis C unrelated to this manuscript. JSD’s institution has received investigator-initiated research funding from Gilead Sciences and AbbVie and honoraria from Gilead Sciences and AbbVie. AJS’s institution has received investigator-initiated research funding from Merck, Sharp and Dohme.
(© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Investigator: E Athan; L Attwood; M Bryant; J Davis; J Doyle; P Higgs; N Holmes; S Lee; K McCarthy; S Miyakis; K O'Callaghan; B Rogers; N Runnegar; M Sehu; S Sparham; A Stewardson; S Tong; O Vujovic
Keywords: Epidemiology; INFECTIOUS DISEASES; Substance misuse
سلسلة جزيئية: ANZCTR ACTRN12622001173785
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20230403 Date Completed: 20230405 Latest Revision: 20230412
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10083776
DOI: 10.1136/bmjopen-2022-070236
PMID: 37012020
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2022-070236