دورية أكاديمية
أعرض في EDS

Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.

التفاصيل البيبلوغرافية
العنوان: Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.
المؤلفون: Houlder EL; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.; Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands., Costain AH; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.; Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands., Nambuya I; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.; MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda., Brown SL; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Koopman JPR; Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands., Langenberg MCC; Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands., Janse JJ; Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands., Hoogerwerf MA; Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands., Ridley AJL; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Forde-Thomas JE; Department of Life Sciences, Aberystwyth University, Aberystwyth, SY23 3DA, UK., Colombo SAP; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Winkel BMF; Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands., Galdon AA; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Hoffmann KF; Department of Life Sciences, Aberystwyth University, Aberystwyth, SY23 3DA, UK., Cook PC; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK., Roestenberg M; Leiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Centre, Leiden, Netherlands., Mpairwe H; MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda., MacDonald AS; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK. Andrew.MacDonald@manchester.ac.uk.
المصدر: Nature communications [Nat Commun] 2023 Apr 03; Vol. 14 (1), pp. 1863. Date of Electronic Publication: 2023 Apr 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Schistosomiasis*/parasitology , Schistosomiasis mansoni* , Pneumonia*, Humans ; Mice ; Animals ; Schistosoma mansoni/physiology ; Case-Control Studies ; Cytokines ; Dendritic Cells
مستخلص: Schistosomiasis is a parasitic disease affecting over 200 million people in multiple organs, including the lungs. Despite this, there is little understanding of pulmonary immune responses during schistosomiasis. Here, we show type-2 dominated lung immune responses in both patent (egg producing) and pre-patent (larval lung migration) murine Schistosoma mansoni (S. mansoni) infection. Human pre-patent S. mansoni infection pulmonary (sputum) samples revealed a mixed type-1/type-2 inflammatory cytokine profile, whilst a case-control study showed no significant pulmonary cytokine changes in endemic patent infection. However, schistosomiasis induced expansion of pulmonary type-2 conventional dendritic cells (cDC2s) in human and murine hosts, at both infection stages. Further, cDC2s were required for type-2 pulmonary inflammation in murine pre-patent or patent infection. These data elevate our fundamental understanding of pulmonary immune responses during schistosomiasis, which may be important for future vaccine design, as well as for understanding links between schistosomiasis and other lung diseases.
(© 2023. The Author(s).)
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معلومات مُعتمدة: MC_UU_00033/3 United Kingdom MRC_ Medical Research Council; MR/W018748/1 United Kingdom MRC_ Medical Research Council; 107475/Z/15/Z United Kingdom WT_ Wellcome Trust; BB/P504543/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council
المشرفين على المادة: 0 (Cytokines)
تواريخ الأحداث: Date Created: 20230403 Date Completed: 20230405 Latest Revision: 20240221
رمز التحديث: 20240221
مُعرف محوري في PubMed: PMC10070318
DOI: 10.1038/s41467-023-37502-z
PMID: 37012228
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-37502-z