دورية أكاديمية
PDGF receptor signal mediates the contribution of Nestin-positive cell lineage to subcutaneous fat development.
| العنوان: | PDGF receptor signal mediates the contribution of Nestin-positive cell lineage to subcutaneous fat development. |
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| المؤلفون: | Takashima Y; Department of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan; Department of Oral and Maxillofacial Surgery, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan., Yamamoto S; Department of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan. Electronic address: seiyama@med.u-toyama.ac.jp., Okuno N; Department of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan., Hamashima T; Department of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan., Dang ST; Department of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan; Department of Pathology and Forensic Medicine, The 103 Military Hospital, Vietnam Military Medical University, Hanoi, Viet Nam., Tran ND; Department of Pathology and Forensic Medicine, The 103 Military Hospital, Vietnam Military Medical University, Hanoi, Viet Nam., Okita N; Department of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan., Miwa F; Department of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan., Dang TC; Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Viet Nam., Matsuo M; Division of Animal Resources and Development, Life Science Research Center, University of Toyama, Toyama, 930-0194, Japan., Takao K; Division of Animal Resources and Development, Life Science Research Center, University of Toyama, Toyama, 930-0194, Japan., Fujimori T; Division of Embryology, National Institute for Basic Biology, Okazaki, 444-8787, Japan., Mori H; Department of Molecular Neuroscience, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan., Tobe K; First Department of Internal Medicine, University of Toyama, Japan University of Toyama, Toyama, 930-0194, Japan., Noguchi M; Department of Oral and Maxillofacial Surgery, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan., Sasahara M; Department of Pathology, Academic Assembly Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan. Electronic address: sasahara@med.u-toyama.ac.jp. |
| المصدر: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 May 28; Vol. 658, pp. 27-35. Date of Electronic Publication: 2023 Mar 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002- >: San Diego, CA : Elsevier Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Receptor, Platelet-Derived Growth Factor alpha*/metabolism , Adipocytes*/metabolism, Mice ; Animals ; Cell Lineage ; Adipose Tissue, White/metabolism ; Adipogenesis/genetics ; Subcutaneous Fat/metabolism |
| مستخلص: | The beiging of white adipose tissue (WAT) is expected to improve systemic metabolic conditions; however, the regulation and developmental origin of this process remain insufficiently understood. In the present study, the implication of platelet-derived growth factor receptor alpha (PDGFRα) was examined in the beiging of inguinal WAT (ingWAT) of neonatal mice. Using in vivo Nestin expressing cell (Nestin + ) lineage tracing and deletion mouse models, we found that, in the mice with Pdgfra gene inactivation in Nestin + lineage (N-PRα-KO mice), the growth of inguinal WAT (ingWAT) was suppressed during neonatal periods as compared with control wild-type mice. In the ingWAT of N-PRα-KO mice, the beige adipocytes appeared earlier that were accompanied by the increased expressions of both adipogenic and beiging markers compared to control wild-type mice. In the perivascular adipocyte progenitor cell (APC) niche of ingWAT, many PDGFRα + cells of Nestin + lineage were recruited in Pdgfra-preserving control mice, but were largely decreased in N-PRα-KO mice. This PDGFRα + cell depletion was replenished by PDGFRα + cells of non-Nestin + lineage, unexpectedly resulting in an increase of total PDGFRα + cell number in APC niche of N-PRα-KO mice over that of control mice. These represented a potent homeostatic control of PDGFRα + cells between Nestin + and non-Nestin + lineages that was accompanied by the active adipogenesis and beiging as well as small WAT depot. This highly plastic nature of PDGFRα + cells in APC niche may contribute to the WAT remodeling for the therapeutic purpose against metabolic diseases. Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Adipocyte progenitor cell; Beiging; Nestin expressing cell lineage; PDGFRα |
| المشرفين على المادة: | EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha) |
| تواريخ الأحداث: | Date Created: 20230405 Date Completed: 20230421 Latest Revision: 20230426 |
| رمز التحديث: | 20230427 |
| DOI: | 10.1016/j.bbrc.2023.03.052 |
| PMID: | 37018886 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2104 |
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| DOI: | 10.1016/j.bbrc.2023.03.052 |