دورية أكاديمية
The Prevalence of Cardiovascular Manifestations in Pediatric Sickle Cell Anemia Patients in a Large Tertiary Care Hospital in the Western Region of Saudi Arabia.
| العنوان: | The Prevalence of Cardiovascular Manifestations in Pediatric Sickle Cell Anemia Patients in a Large Tertiary Care Hospital in the Western Region of Saudi Arabia. |
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| المؤلفون: | Waggass R; Pediatric Cardiology, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Alhindi AK; Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU., Bagabas IS; Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU., Alsaegh MH; Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; College of Medicine, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia, Jeddah, SAU., Alsharef NK; Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU., Morya RE; Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU.; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU., Khan MA; Medical Education, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.; Research, King Abdullah International Medical Research Center, Jeddah, SAU.; College of Medicine, King Abdulaziz Medical City, Jeddah, SAU., Jastaniah W; Oncology, King Faisal Specialist Hospital and Research Centre, Jeddah, SAU. |
| المصدر: | Cureus [Cureus] 2023 Mar 04; Vol. 15 (3), pp. e35751. Date of Electronic Publication: 2023 Mar 04 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Palo Alto, CA : Cureus, Inc. |
| مستخلص: | Background Sickle cell disease (SCD) is a common hematological disorder with a high prevalence in Saudi Arabia. Despite that, limited studies are available in our region regarding cardiovascular complications. Objectives The objective of the current study was to estimate the prevalence of cardiovascular complications among children with SCD. Design This was a cross-sectional study. Setting The study took place at a single tertiary-care center in Jeddah, Saudi Arabia. Materials and methods The study reviewed 126 electronic records of pediatric patients up to 16 years old diagnosed with SCD between January 2008 and December 2019 in King Abdulaziz Medical City (KAMC) in Jeddah, Saudi Arabia. Of these, 54 patients had a previous echocardiogram evaluation and were eligible for the study. Main outcomes measures The study identified cardiovascular complications in pediatric sickle cell patients. Sample size The study included a total of 54 pediatric sickle cell patients. Results The mean age was 11.9 (3.48) years, the male-to-female ratio was 2:1, the majority (94.4%) had the HbSS-HbSβ0 genotype, the mean baseline hemoglobin F (fetal hemoglobin) was 20.30 (9.03%), and the clinical severity score was severe in 19 (35.2%) and mild/moderate in 35 (64.8%) patients. Cardiovascular complications occurred in 32 (59.3%) patients. Increased systolic blood pressure was detected in 10 (18.5%) patients. Echocardiography showed left ventricular dilatation in nine (16.7%) patients, tricuspid valve insufficiency in six (11.1%) patients, mitral valve insufficiency in four (7.4%) patients, hyperdynamic left ventricle in one (1.9%) patient, and pulmonary hypertension in one (1.9%) patient. Long QTc interval was noticed in three (5.6%) and cardiomegaly was detected in 18 (33.3%) patients. Conclusion Cardiovascular complications occurred at a high frequency in our pediatric population despite high baseline hemoglobin F levels. Early evaluation and continuous monitoring are important for early intervention. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Waggass et al.) |
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| فهرسة مساهمة: | Keywords: cardiovascular complications; children; high systolic blood pressure; hyperdynamic left ventricle; left ventricular dilatation; mitral valve insufficiency; pulmonary hypertension; saudi arabia; sickle cell disease; tricuspid valve insufficiency |
| تواريخ الأحداث: | Date Created: 20230406 Latest Revision: 20230407 |
| رمز التحديث: | 20230407 |
| مُعرف محوري في PubMed: | PMC10069165 |
| DOI: | 10.7759/cureus.35751 |
| PMID: | 37020484 |
| قاعدة البيانات: | MEDLINE |
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