دورية أكاديمية
أعرض في EDS

Naringenin stimulates osteogenic/odontogenic differentiation and migration of human dental pulp stem cells.

التفاصيل البيبلوغرافية
العنوان: Naringenin stimulates osteogenic/odontogenic differentiation and migration of human dental pulp stem cells.
المؤلفون: Kim Y; Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan, South Korea.; Periodontal Disease Signaling Network Research Center (MRC), Pusan National University, Yangsan, South Korea.; Dental and Life Science Institute, Pusan National University, Yangsan, South Korea., Park HJ; Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan, South Korea.; Periodontal Disease Signaling Network Research Center (MRC), Pusan National University, Yangsan, South Korea.; Dental and Life Science Institute, Pusan National University, Yangsan, South Korea., Kim MK; Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan, South Korea.; Periodontal Disease Signaling Network Research Center (MRC), Pusan National University, Yangsan, South Korea., Kim YI; Department of Orthodontics, School of Dentistry, Pusan National University, Yangsan, South Korea., Kim HJ; Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan, South Korea.; Periodontal Disease Signaling Network Research Center (MRC), Pusan National University, Yangsan, South Korea.; Dental and Life Science Institute, Pusan National University, Yangsan, South Korea., Bae SK; Periodontal Disease Signaling Network Research Center (MRC), Pusan National University, Yangsan, South Korea.; Dental and Life Science Institute, Pusan National University, Yangsan, South Korea.; Department of Dental Pharmacology, School of Dentistry, Pusan National University, Yangsan, South Korea., Nör JE; Department of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA., Bae MK; Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan, South Korea.; Periodontal Disease Signaling Network Research Center (MRC), Pusan National University, Yangsan, South Korea.; Dental and Life Science Institute, Pusan National University, Yangsan, South Korea.
المصدر: Journal of dental sciences [J Dent Sci] 2023 Apr; Vol. 18 (2), pp. 577-585. Date of Electronic Publication: 2022 Sep 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101293181 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-8862 (Electronic) Linking ISSN: 19917902 NLM ISO Abbreviation: J Dent Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Amsterdam] : Elsevier B.V.
Original Publication: Taipei, Taiwan : Association for Dental Sciences of the Republic of China, 2006-
مستخلص: Background/purpose: Naringenin, a naturally occurring flavanone in citrus fruits, regulates bone formation by bone marrow-derived mesenchymal stem cells. The purpose of this study was to characterize the effects of naringenin on some biological behaviors of human dental pulp stem cells (HDPSCs).
Materials and Methods: HDPSCs were cultured in osteogenic differentiation medium and osteo/odontogenic differentiation and mineralization were analyzed by alkaline phosphatase (ALP) staining and Alizarin Red S (ARS) staining. The migration of HDPSCs was evaluated by transwell chemotactic migration assays and scratch wound healing migration assay. Using tooth slice/scaffold model, we assessed the in vivo odontogenic differentiation potential of HDPSCs.
Results: We have demonstrated that naringenin increases the osteogenic/odontogenic differentiation of HDPSCs through regulation of osteogenic-related proteins and the migratory ability of HDPSCs through stromal cell derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis. Moreover, naringenin promotes the expression of dentin matrix acidic phosphoprotein-1 (DMP-1) and dentin sialophosphoprotein (DSPP) in HDPSCs seeded on tooth slice/scaffolds that are subcutaneously implanted into immunodeficient mice.
Conclusion: Our present study suggests that naringenin promotes migration and osteogenic/odontogenic differentiation of HDPSCs and may serve as a promising candidate in dental tissue engineering and bone regeneration.
Competing Interests: The authors declare that they have no conflicts of interest.
(© 2022 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.)
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معلومات مُعتمدة: R37 DE021410 United States DE NIDCR NIH HHS
فهرسة مساهمة: Keywords: Differentiation; Human dental pulp stem cells; Migration; Naringenin
تواريخ الأحداث: Date Created: 20230406 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC10068380
DOI: 10.1016/j.jds.2022.08.029
PMID: 37021242
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-8862
DOI:10.1016/j.jds.2022.08.029