دورية أكاديمية
أعرض في EDS

Targeted delivery of pexidartinib to tumor-associated macrophages via legumain-sensitive dual-coating nanoparticles for cancer immunotherapy.

التفاصيل البيبلوغرافية
العنوان: Targeted delivery of pexidartinib to tumor-associated macrophages via legumain-sensitive dual-coating nanoparticles for cancer immunotherapy.
المؤلفون: Liang DS; School of Pharmacy, Nanchang University, Nanchang, PR China., You WP; School of Pharmacy, Nanchang University, Nanchang, PR China., Zhu FF; School of Pharmacy, Nanchang University, Nanchang, PR China., Wang JH; School of Pharmacy, Nanchang University, Nanchang, PR China., Guo F; School of Pharmacy, Nanchang University, Nanchang, PR China., Xu JJ; Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, PR China., Liu XL; Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, PR China., Zhong HJ; School of Pharmacy, Nanchang University, Nanchang, PR China; Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, PR China. Electronic address: zhonghj@ncu.edu.cn.
المصدر: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2023 Jun; Vol. 226, pp. 113283. Date of Electronic Publication: 2023 Mar 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, c1993-
مواضيع طبية MeSH: Nanoparticles* , Neoplasms*, Tumor-Associated Macrophages ; Cell Line, Tumor ; Immunotherapy/methods ; Tumor Microenvironment
مستخلص: Tumor-associated macrophage (TAM) is regarded as an appealing cell target for cancer immunotherapy. However, it remains challenging to selectively eliminate M2-like TAM in tumor microenvironment. In this work, we employed a legumain-sensitive dual-coating nanosystem (s-T pep -NPs) to deliver CSF-1R inhibitor pexidartinib (PLX3397) for targeting TAM therapy. The PLX3397-loaded NPs exhibited uniform size of ∼240 nm in diameter, good drug loading capacity and efficiency, as well as sustained drug release profile. Compared to non-sensitive counterpart ns-T pep -NPs, s-T pep -NPs showed distinguished selectivity upon M1 and M2 macrophage uptake with relation to incubation time and dose. Besides, the selectivity of anti-proliferation effect was also identified for s-T pep -NPs against M1 and M2 macrophage. In vivo imaging demonstrated that s-T pep -NPs exhibited much higher tumoral accumulation and TAM recognition specificity as compared to non-sensitive ns-T pep -NPs. In vivo efficacy verified that s-T pep -NPs formulation was much more effective than ns-T pep -NPs and other PLX3397 formulations to treat B16F10 melanoma via targeting TAM depletion and modulating tumor immune microenvironment. Overall, this study provides a robust and promising nanomedicine strategy for TAM-targeted cancer immunotherapy.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Cancer immunotherapy; Dual-coating nanoparticles; Pexidartinib; Targeted delivery; Tumor-associated macrophage
المشرفين على المادة: 6783M2LV5X (pexidartinib)
EC 3.4.22.34 (asparaginylendopeptidase)
تواريخ الأحداث: Date Created: 20230408 Date Completed: 20230602 Latest Revision: 20230602
رمز التحديث: 20231215
DOI: 10.1016/j.colsurfb.2023.113283
PMID: 37030033
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4367
DOI:10.1016/j.colsurfb.2023.113283